Progress towards a vaccine for schistosomiasis
Progress towards a vaccine for schistosomiasis
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DOI：
10.1016/s0001-706x(03)00062-7
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发表时间：
2003-05-01
期刊：
影响因子：
2.7
通讯作者：
Pearce, EJ
中科院分区：
文献类型：
--
作者：
Pearce, EJ
血吸虫病仍然是一个重大的健康问题，特别是在非洲。虽然最近世界卫生大会决议对流行地区学龄儿童进行大规模药物治疗是一个非常有希望的进展，但保护性疫苗将提供更好的长期解决方案。令人鼓舞的是，一种疫苗 Bilhvax 正在进行二期试验。然而，存在着开发血吸虫病疫苗这一目标的势头正在减弱的危险。本文综述了血吸虫病这一重要领域的研究现状。 (C) 2003 Elsevier Science B.V. 保留所有权利。
Schistosomiasis continues to be a significant health problem, especially in Africa. While the recent World Health Assembly resolution to apply mass drug treatment of school age children in endemic areas is a very promising development, a preferable long-term solution would be provided by a protective vaccine. Encouragingly, one vaccine, Bilhvax, is in phase II trials. However, there is a danger that momentum towards the goal of developing a vaccine against schistosomiasis is dissipating. This article reviews the current situation in this important area of schistosomiasis research. (C) 2003 Elsevier Science B.V. All rights reserved.