Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function
Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function
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DOI：
10.1136/heartjnl-2011-301388
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发表时间：
2012-05-01
期刊：
影响因子：
5.7
通讯作者：
Di Tullio, Marco R.
中科院分区：
文献类型：
--
作者：
Russo, Cesare;Jin, Zhezhen;Di Tullio, Marco R.
目的左心房（LA）最大容积（LAV（max））是左心室（LV）舒张功能的指标。然而，LAV（max）也受收缩期事件的影响，而LA最小容积（LAV（min））直接暴露于LV压力。作者假设，LAV（min）可能是一个更好的相关性左心室舒张功能比LAV（max）。设计横断面。设置大学hospital.Patients 357参与者从一个社区为基础的队列study.Methods左心房容积和水库功能，测量总左心房排空容积（LAEV）和左心房排空分数（LAEF），通过实时三维超声心动图进行了评估。通过经二尖瓣早期（E）和晚期（A）多普勒速度以及通过组织多普勒（e '）评估二尖瓣早期舒张速度来评估LV舒张功能。结果随着舒张功能不全的加重，LAV（min）明显增加（p< 0.001），而LAVmax的增加不明显（p> 0.07）。LAEV和LAEF随着舒张功能障碍的恶化而降低（均p< 0.001）。在线性回归中，LAV（min）和LAV（max）是E/e '的显著预测因子，LAV（min）的参数估计值较高。在多变量模型中，LAV（min）与E/e'（β =0.45，p
Objective Left atrial (LA) maximum volume (LAV(max)) is an indicator of left ventricular (LV) diastolic function. However, LAV(max) is also influenced by systolic events, whereas the LA minimum volume (LAV(min)) is directly exposed to LV pressure. The authors hypothesised that LAV(min) may be a better correlate of LV diastolic function than LAV(max).Design Cross-sectional.Setting University hospital.Patients 357 participants from a community-based cohort study.Methods LA volumes and reservoir function, measured as total LA emptying volume (LAEV) and LA emptying fraction (LAEF), were assessed by real-time threedimensional echocardiography. LV diastolic function was assessed by trans-mitral early (E) and late (A) Doppler velocities and mitral early diastolic velocity by tissueDoppler (e'). LV systolic function was assessed by LV ejection fraction (LVEF) and global longitudinal strain (GLS) by speckle-tracking.Results LAV(min) significantly increased with worsening diastolic dysfunction (p< 0.001), whereas the increase in LAVmax was less pronounced (p 0.07). LAEV and LAEF decreased with worsening diastolic dysfunction (both p< 0.001). In linear regressions, LAV(min) and LAV(max) were significant predictors of E/e', with higher parameter estimates for LAV(min). In multivariate models, LAV(min) resulted strongly associated with E/e' (beta=0.45, p