The impact of supplementary immunization activities on the epidemiology of measles in Tianjin, China.
The impact of supplementary immunization activities on the epidemiology of measles in Tianjin, China.
复制标题
补充免疫活动对中国天津市麻疹流行病学的影响。
DOI：
10.1016/j.ijid.2016.03.005
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Boulton,MatthewL
中科院分区：
文献类型：
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作者：
Wagner,AbramL;Zhang,Ying;Mukherjee,Bhramar;Ding,Yaxing;Wells,EdenV;Boulton,MatthewL
中国已经多次使用补充免疫活动（SIAs）来消除麻疹，但尚不清楚SIAs是否覆盖了非本地人-从农村到城市的流动人口。本研究的特点是时间的变化趋势，麻疹发病率的本地和非本地居住和评估的影响SIAs对麻疹发病率在天津，China.MethodsDaily麻疹病例计数分别制表居住。将这两个数据集合并，以便每天有两个观察结果。Poisson回归采用广义估计方程和可交换工作相关结构估计率比（RRs.ResultsThere是12 465例麻疹病例在天津的10年期间。在2008年SIA之前，非本地人的麻疹发病率高于本地人（RR 3.60，95%置信区间（CI）3.27-3.96），但在2008年和2010年SIA之间，这一比例下降至RR 1.22（95% CI 1.02-1.45）。继2010年SIA，非本地人有较低的麻疹发病率（RR 0.78，95%CI 0.69-0.87）。鉴于中国各地人口的持续流动，需要持续的公共卫生干预措施来维持非本地人的低麻疹发病率。
ObjectivesChina has repeatedly used supplemental immunization activities (SIAs) to work towards measles elimination, but it is unknown if the SIAs are reaching non-locals – migrants from rural to urban areas. This study characterized temporal trends in measles incidence by local and non-local residency and evaluated the impact of SIAs on measles incidence in Tianjin, China.MethodsDaily measles case-counts were tabulated separately by residency. These two datasets were combined so that each day had two observations. Poisson regression was conducted using generalized estimating equations with an exchangeable working correlation structure to estimate rate ratios (RRs).ResultsThere were 12 465 measles cases in Tianjin over the 10-year period. The rate of measles was higher in non-locals than locals before the 2008 SIA (RR 3.60, 95% confidence interval (CI) 3.27–3.96), but this attenuated to a RR of 1.22 between the 2008 and 2010 SIAs (95% CI 1.02–1.45). Following the 2010 SIA, non-locals had a lower rate of measles (RR 0.78, 95% CI 0.69–0.87).ConclusionsThe disparity in measles incidence between locals and non-locals was reduced following two SIAs. Sustained public health interventions will be needed to maintain low measles incidence among non-locals given the ongoing migration of people throughout China.