ELECTRON-MICROSCOPIC STUDIES ON MULTINUCLEATE FOREIGN-BODY GIANT-CELLS DERIVED FROM KUPFFER CELLS IN MICE GIVEN INDIAN INK INTRAVENOUSLY
ELECTRON-MICROSCOPIC STUDIES ON MULTINUCLEATE FOREIGN-BODY GIANT-CELLS DERIVED FROM KUPFFER CELLS IN MICE GIVEN INDIAN INK INTRAVENOUSLY
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DOI：
10.1007/bf02890368
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
YAMASHITA, K
中科院分区：
文献类型：
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作者：
FUJITA, H;KAWAMATA, S;YAMASHITA, K
用电镜观察了印度墨水灌胃小鼠后库普弗细胞的变化。库普弗细胞和肝窦内皮细胞通过胞饮作用摄取印度墨水颗粒。少量伊藤细胞和肝细胞摄取少量颗粒。在所有细胞类型中，C颗粒都储存在细胞质液泡中。注射后3、4天，在窦腔、椎间盘间隙和小叶间结缔组织间隙可见库普弗细胞聚集物，其中含有大量塞满C颗粒的液泡。注射后1小时，在椎间盘间隙和其他结缔组织间隙内可见大量聚集的库普弗细胞，其中含有大量充满c的液泡。这些团块中的库普弗细胞紧密接触，部分融合在一起。3、4、6个月后，肝组织可见大的多核异物体巨细胞，有大量的大液泡，其中含有密集堆积的墨水颗粒。它们可能是由库普弗细胞融合形成的。一些内皮细胞也在注射后将墨水颗粒储存在细胞质空泡中长达6个小时。
Changes in Kupffer cells in mice given i.v. Indian ink were studied with EM. Kupffer and hepatic sinusoidal endothelial cells took up Indian ink particles by pinocytosis. A few Ito cells and heptocytes ingested a small number of particles. The C particles were stored in cytoplasmic vacuoles in all cell types. Aggregates of Kupffer cells containing many vacuoles stuffed with C particles were seen in the sinusoidal lumen, Disse space and interlobular connective tissue space 3 and 4 days after injection, with Indian ink. One mo. after injection large clumps of aggregated Kupffer cells containing numerous C-filled vacuoles were distributed in the Disse space and other connective tissue spaces. The Kupffer cells in these clumps were in close contact and were partly fused with one another. After 3, 4 and 6 mo., large multinucleate foreign body giant cells with numerous large vacuoles containing densely-packed ink particles were seen throughout the liver tissue. They were probably formed by fusion of Kupffer cells. Some endothelial cells also stored ink particles in cytoplasmic vacuoles for as long as 6 mo. after injection.