Chronic eosinophilic pneumonia. Ultrastructural evidence of marked immunoglobulin production plus macrophagic ingestion of eosinophils and eosinophilic lysosomes leading to intracytoplasmic Charcot-Leyden crystals.
Chronic eosinophilic pneumonia. Ultrastructural evidence of marked immunoglobulin production plus macrophagic ingestion of eosinophils and eosinophilic lysosomes leading to intracytoplasmic Charcot-Leyden crystals.
复制标题
慢性嗜酸细胞性肺炎。
作者：
R. Fienberg
一名60岁男性被诊断为慢性嗜酸性粒细胞肺炎的临床表现和开放肺活检。活检组织的电子显微镜研究显示免疫球蛋白的显著产生的证据，这可能是吸引大量嗜酸性粒细胞进入该区域的趋化过程的一部分。此外，还有吞噬变性嗜酸性粒细胞和嗜酸性溶酶体的巨噬细胞。在许多巨噬细胞的细胞质中观察到Charcot-Leyden晶体。本文还讨论了免疫球蛋白的产生与嗜酸性粒细胞增多的关系及巨噬细胞内Charcot-Leyden晶体的形成机制。
A 60-year-old man was diagnosed as having chronic eosinophilic pneumonia by clinical presentation and open lung biopsy. Electron microscopic study of the tissue from biopsy revealed evidence of marked production of immunoglobulin, which may be part of the chemotactic process which attracted large numbers of eosinophils into the area. Also, there were macrophages which were phagocytosing degenerating eosinophils and eosinophilic lysosomes. Charcot-Leyden crystals were noted in the cytoplasm of many macrophages. The relationship of the production of immunoglobulin to the eosinophilia and the mechanism of intramacrophagic formation of Charcot-Leyden crystals is discussed.