Esthesioneuroblastoma: Irradiation alone and surgery alone are not enough
Esthesioneuroblastoma: Irradiation alone and surgery alone are not enough
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DOI：
10.1016/s0360-3016(02)02941-3
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发表时间：
2002-10-01
影响因子：
7
通讯作者：
Greiner, R
中科院分区：
文献类型：
--
作者：
Gruber, GN;Laedrach, K;Greiner, R
Purpose: To evaluate the long-term outcome of patients with esthesioneuroblastoma treated with neoadjuvant or definitive radiotherapy (RT).Methods and Materials: Between 1980 and 2001, 28 patients with histologically confirmed esthesioneuroblastoma underwent RT, with a median dose of 60 Gy (range 38-73). The median age was 58 years (range 16-85). According to the Kadish classification, 4 patients had Stage A, 8 Stage B, and 16 Stage C tumors. Radical resection was performed in 13 cases, in 9 before RT and in 4 after RT because of stable or progressive disease. The outcome analyses included the median age (58 years), Kadish stage, skull base penetration, intraorbital extension, resection status, and total dose (less than or equal to60 vs. >60 Gy).Results: After a mean follow-up of 68 months, 54% of patients were free of tumor progression. The 5-and 10-year local progression-free survival rate was 81% and 51%, respectively, and the disease-free survival rate was 70% and 25%, respectively. Four of ten deaths (4/10) were intercurrent, resulting in a cause-specific survival of 77% and 69% at 5 and 10 years, respectively. Radical resection offered significantly better local progression-free survival and disease-free survival (p
