The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?
The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?
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DOI：
10.1016/j.physbeh.2015.05.031
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发表时间：
2015-12-01
影响因子：
2.9
通讯作者：
Hopkins, M.
中科院分区：
文献类型：
--
作者：
Blundell, J. E.;Finlayson, G.;Hopkins, M.
流行的稳态食欲控制模型设想了两个主要的输入：来自脂肪组织的信号和来自胃肠道中的肽激素的信号。该模型基于脂肪组织对食物摄入的假定主要影响。然而，最近的研究表明，在肥胖人群中，无脂肪质量（FFM）与每日能量摄入量和膳食量密切相关。这种效应在文化和种族背景不同的几个独立群体中得到了复制，似乎是一种强有力的现象。相反，脂肪量（FM）与肥胖人群的食物摄入量呈弱相关或轻度负相关。此外，静息代谢率（RMR），每日总能量消耗的主要组成部分，也与食物摄入量有关。这种效应在不同的群体中得到了复制，并且是稳健的。这一行动与RMR中反映的能量需求（以及能量消耗的其他方面）构成进食的生物驱动力的提议一致。与其储存功能一致，FM对瘦受试者的食物摄入具有强烈的抑制作用，但这种作用似乎随着脂肪组织的增加而显著减弱。这种配方可以解释肥胖的发展和维持的几个特征，并提供了一种替代的，透明的，食欲控制生物学的方法。(C)由Elsevier Inc.出版。
The prevailing model of homeostatic appetite control envisages two major inputs; signals from adipose tissue and from peptide hormones in the gastrointestinal tract. This model is based on the presumed major influence of adipose tissue on food intake. However, recent studies have indicated that in obese people fat-free mass (FFM) is strongly positively associated with daily energy intake and with meal size. This effect has been replicated in several independent groups varying in cultural and ethnic backgrounds, and appears to be a robust phenomenon. In contrast fat mass (FM) is weakly, or mildly negatively associated with food intake in obese people. In addition resting metabolic rate (RMR), a major component of total daily energy expenditure, is also associated with food intake. This effect has been replicated in different groups and is robust. This action is consistent with the proposal that energy requirements reflected in RMR (and other aspects of energy expenditure) constitute a biological drive to eat. Consistent with its storage function, FM has a strong inhibitory effect on food intake in lean subjects, but this effect appears to weaken dramatically as adipose tissue increases. This formulation can account for several features of the development and maintenance of obesity and provides an alternative, and transparent, approach to the biology of appetite control. (C) 2015 Published by Elsevier Inc.