NUTRIENT-CONDITIONED FLAVOR PREFERENCE AND ACCEPTANCE IN RATS - EFFECTS OF DEPRIVATION STATE AND NONREINFORCEMENT
NUTRIENT-CONDITIONED FLAVOR PREFERENCE AND ACCEPTANCE IN RATS - EFFECTS OF DEPRIVATION STATE AND NONREINFORCEMENT
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DOI：
10.1016/0031-9384(94)90230-5
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发表时间：
1994-10-01
影响因子：
2.9
通讯作者：
SCLAFANI, A
中科院分区：
文献类型：
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作者：
DRUCKER, DB;ACKROFF, K;SCLAFANI, A
大鼠获得强烈的偏好与胃内（IG）多糖输注配对的口味。本研究调查了这些口味的摄食反应时，他们不再加强。首先训练所有大鼠在23小时/天的时间段内将CS+风味剂与IG 32%多糖相关联以及将CS-风味剂与IG水相关联。实验1研究了剥夺对非强化条件下短期（4小时/天）CS摄入量的影响。食物剥夺选择性地增强CS+摄入，而水剥夺增加CS+和CS-摄入。结果还表明，灭绝训练差异影响CS+偏好和接受的相对和绝对摄入量。这在第二个实验中得到了证实。当不再与IG多糖输注配对时，大鼠在4小时/天期间CS+溶液的绝对摄入量显著降低;但在4小时和23小时/天试验中，大鼠继续显示出对CS+的强烈偏好。实验3考察了广泛的长期消退训练对CS+偏好的影响。当替代品是白开水时，CS+偏好在12天内消失。然而，相同的大鼠在12个额外的灭绝日和16个灭绝日期间，在1个月的休息期后，继续喜欢CS+而不是CS-。只有当CS+与食物剥夺配对，CS-与食物饱食配对时，相对于CS-的CS+偏好才被阻断。这些实验证实了早先的报道，即多糖调节的风味偏好对消失的抵抗力，但也表明风味接受更容易消失。然而，风味接受并没有完全消失，并且仍然对剥夺状态有反应。
Rats acquire strong preferences for flavors paired with intragastric (IG) Polycose infusions. The present study investigated the ingestive responses to these flavors when they were no longer reinforced. All rats were first trained to associate a CS+ flavor with IG 32% Polycose and a CS- flavor with IG water during 23 h/day sessions. Experiment. 1 examined the effects of deprivation on short-term (4 h/day) CS intakes under nonreinforcement conditions. Food deprivation selectively enhanced CS+ intake whereas water deprivation increased both CS+ and CS- intakes. The results also suggested that extinction training differentially affects CS+ preference and acceptance as measured by relative and absolute intakes. This was confirmed in a second experiment. The rats' absolute intake of the CS+ solution during 4 h/day sessions significantly decreased when it was no longer paired with IG Polycose infusions; yet the rats continued to show a strong preference for the CS+ over the CS- in both 4 h and 23 h/day tests. Experiment 3 examined the effects of extensive long-term extinction training on the CS+ preference. When the alternative was plain water, the CS+ preference extinguished over 12 days. Yet the same rats continued to prefer the CS+ to the CS- during 12 additional extinction days and during 16 extinction days that followed a 1-month rest period. The CS+ preference relative to the CS- was blocked only when the CS+ was paired with food deprivation and the CS- was paired with food repletion. These experiments confirm earlier reports of the resistance of Polycose-conditioned flavor preferences to extinction but also show that flavor acceptance is more susceptible to extinction. Flavor acceptance was not completely extinguished, however, and remained responsive to deprivation state.