Anticipation of high arousal aversive and positive movie clips engages common and distinct neural substrates
Anticipation of high arousal aversive and positive movie clips engages common and distinct neural substrates
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DOI：
10.1093/scan/nsu091
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发表时间：
2015-04-01
影响因子：
4.2
通讯作者：
Mujica-Parodi, Lilianne
中科院分区：
文献类型：
--
作者：
Greenberg, Tsafrir;Carlson, Joshua M.;Mujica-Parodi, Lilianne
焦虑预期的神经相关性主要是在厌恶和中性刺激下研究的。在本研究中，我们通过使用高唤醒厌恶和积极刺激以及不确定条件（即积极或厌恶）来检验效价对预期的影响。这项任务包括预先确定的线索，警告参与者即将到来的厌恶、积极、“不确定”（厌恶或积极）和中性的电影片段。所有情感片段的预期都涉及与情感体验、持续注意力和评价相关的共同区域，包括前岛、前扣带皮层背侧、丘脑、尾状皮层、顶叶下皮层和前额叶皮层。相反，与奖励处理有关的伏隔核和内侧前额叶皮层在期待积极片段（描绘露骨的色情内容）时选择性参与，而与处理厌恶刺激有关的中脑岛在期待厌恶片段（描绘生动的医疗过程）时选择性参与；这三个区域在预期“不确定”片段时也被激活，反映了对厌恶和积极刺激的广泛准备反应。这些结果表明，在对情感片段的预期中，一个共同的回路被招募，而不管其效价如何，其他区域则优先参与，这取决于预期的刺激是消极的还是积极的。
The neural correlates of anxious anticipation have been primarily studied with aversive and neutral stimuli. In this study, we examined the effect of valence on anticipation by using high arousal aversive and positive stimuli and a condition of uncertainty (i.e. either positive or aversive). The task consisted of predetermined cues warning participants of upcoming aversive, positive, 'uncertain' (either aversive or positive) and neutral movie clips. Anticipation of all affective clips engaged common regions including the anterior insula, dorsal anterior cingulate cortex, thalamus, caudate, inferior parietal and prefrontal cortex that are associated with emotional experience, sustained attention and appraisal. In contrast, the nucleus accumbens and medial prefrontal cortex, regions implicated in reward processing, were selectively engaged during anticipation of positive clips (depicting sexually explicit content) and the mid-insula, which has been linked to processing aversive stimuli, was selectively engaged during anticipation of aversive clips (depicting graphic medical procedures); these three areas were also activated during anticipation of 'uncertain' clips reflecting a broad preparatory response for both aversive and positive stimuli. These results suggest that a common circuitry is recruited in anticipation of affective clips regardless of valence, with additional areas preferentially engaged depending on whether expected stimuli are negative or positive.