Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice.
Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice.
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DOI：
10.1002/1873-3468.13221
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发表时间：
2018-09
期刊：
影响因子：
3.5
通讯作者：
LeDoux MS
中科院分区：
文献类型：
--
作者：
Xiao J;Khan MM;Vemula S;Tian J;LeDoux MS
CIZ1 plays a role in DNA synthesis at the G1/S checkpoint. Ciz1 gene-trap null mice manifest motor dysfunction, cell-cycle abnormalities and DNA damage. In contrast, it has previously been reported that mouse embryonic fibroblasts derived from presumed Ciz1 knock-out mice (Ciz1 tm1.1Homy/tm1.1Homy) generated by crossing Cre-expressing mice with exon 5-floxed mice (Ciz1 tm1Homy/tm1Homy) do not exhibit evidence of enhanced DNA damage following γ-irradiation or cell-cycle defects. Here, we report that Ciz1 tm1.1Homy/tm1.1Homy mice show loss of Ciz1 exon 5 but are neurologically normal and express abnormal transcripts (Ciz1ΔE5/ΔE5 mice) that are translated into one or more proteins of approximate wild-type size. Therefore, Ciz1 tm1.1Homy/tm1.1Homy mice (Ciz1ΔE5/ΔE5) lose residues encoded by exon 5 but may gain function from novel amino acid sequences.
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影响因子：
5.3
作者：
Xiao J;Vemula SR;Xue Y;Khan MM;Kuruvilla KP;Marquez-Lona EM;Cobb MR;LeDoux MS
通讯作者：
LeDoux MS
影响因子：
10.5
作者：
Ridings-Figueroa R;Stewart ER;Nesterova TB;Coker H;Pintacuda G;Godwin J;Wilson R;Haslam A;Lilley F;Ruigrok R;Bageghni SA;Albadrani G;Mansfield W;Roulson JA;Brockdorff N;Ainscough JFX;Coverley D
通讯作者：
Coverley D
影响因子：
11.2
作者：
Xiao, Jianfeng;Uitti, Ryan J.;Zhao, Yu;Vemula, Satya R.;Perlmutter, Joel S.;Wszolek, Zbigniew K.;Maraganore, Demetrius M.;Auburger, Georg;Leube, Barbara;Lehnhoff, Katja;LeDoux, Mark S.
通讯作者：
LeDoux, Mark S.
影响因子：
6.1
作者：
Xiao, Jianfeng;Vemula, Satya R.;LeDoux, Mark S.
通讯作者：
LeDoux, Mark S.
影响因子：
3.3
作者：
Turlo, Kirsten A.;Gallaher, Sean D.;Iruela-Arispe, M. Luisa
通讯作者：
Iruela-Arispe, M. Luisa