Starvation Protects Germline Stem Cells and Extends Reproductive Longevity in C-elegans
Starvation Protects Germline Stem Cells and Extends Reproductive Longevity in C-elegans
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DOI：
10.1126/science.1178343
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发表时间：
2009-11-13
期刊：
影响因子：
56.9
通讯作者：
Van Gilst, Marc R.
中科院分区：
文献类型：
--
作者：
Angelo, Giana;Van Gilst, Marc R.
抗饥饿生物程序的研究已经阐明了许多影响衰老的机制。在这里，我们提出了饥饿诱导的成年生殖滞育（ARD）在秀丽隐杆线虫的发现和表征。ARD与C.它使性成熟成虫的生殖开始延迟15倍，并使成虫的总寿命延长至少3倍。ARD的有效性需要整个生殖系的凋亡死亡，除了一小群受保护的生殖系干细胞（GSC）。当恢复喂养时，存活的GSC再生一个新的生殖系，能够产生接近非饥饿动物水平的后代。饥饿感应核受体NHR-49是ARD进入和恢复所必需的。我们的研究结果建立了在长期饥饿期间保持干细胞潜能和生殖潜力的机制。
The study of starvation-resistant biological programs has elucidated numerous mechanisms influencing aging. Here we present the discovery and characterization of starvation-induced adult reproductive diapause (ARD) in Caenorhabditis elegans. ARD differs from the C. elegans dauer diapause in that it enables sexually mature adults to delay reproductive onset 15-fold and extend total adult life span at least threefold. The effectiveness of ARD requires apoptotic death of the entire germ line, except for a small population of protected germline stem cells (GSCs). When feeding is resumed, surviving GSCs regenerate a new germ line capable of offspring production near the level of nonstarved animals. The starvation-sensing nuclear receptor NHR-49 is required for ARD entry and recovery. Our findings establish mechanisms for preserving stem cell potency and reproductive potential during prolonged starvation.