Auditory biological marker of concussion in children
Auditory biological marker of concussion in children
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DOI：
10.1038/srep39009
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发表时间：
2016-12-22
影响因子：
4.6
通讯作者：
LaBella, Cynthia R.
中科院分区：
文献类型：
--
作者：
Kraus, Nina;Thompson, Elaine C.;LaBella, Cynthia R.
脑震荡对认知、神经和社会情感疾病具有毁灭性的潜在影响，但没有客观的测试可靠地识别脑震荡及其严重程度。各种神经损伤损害声音处理，特别是在对大脑处理有高要求的复杂听音环境中。频率跟随响应以极高的粒度捕捉声音处理的高计算要求，并可靠地揭示个体差异。我们假设脑震荡破坏了这些听觉过程，频率跟随反应表明脑震荡的发生和严重程度。具体来说，我们假设脑震荡破坏了基频的处理，基频是识别和跟踪声音和说话者的关键声学线索，因此，理解噪声中的语音。在这里，我们表明，儿童谁持续脑震荡表现出一个签名的神经轮廓。他们对基频的表现更差，神经反应更小、更迟钝。随着脑震荡症状的减轻，对基频的神经生理反应部分恢复到控制水平，这表明部分恢复后生物处理有所增加。声音的神经处理正确识别了90%的脑震荡病例，并清除了95%的对照病例，这表明这种方法具有作为运动相关脑震荡和其他类型轻度创伤性脑损伤的可扩展生物标志物的实际潜力。
Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain processing. The frequency-following response captures the high computational demands of sound processing with extreme granularity and reliably reveals individual differences. We hypothesize that concussions disrupt these auditory processes, and that the frequency-following response indicates concussion occurrence and severity. Specifically, we hypothesize that concussions disrupt the processing of the fundamental frequency, a key acoustic cue for identifying and tracking sounds and talkers, and, consequently, understanding speech in noise. Here we show that children who sustained a concussion exhibit a signature neural profile. They have worse representation of the fundamental frequency, and smaller and more sluggish neural responses. Neurophysiological responses to the fundamental frequency partially recover to control levels as concussion symptoms abate, suggesting a gain in biological processing following partial recovery. Neural processing of sound correctly identifies 90% of concussion cases and clears 95% of control cases, suggesting this approach has practical potential as a scalable biological marker for sports-related concussion and other types of mild traumatic brain injuries.