Emerging Role of MicroRNAs in mTOR Signaling.
Emerging Role of MicroRNAs in mTOR Signaling.
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MicroRNA 在 mTOR 信号传导中的新作用
DOI：
10.1007/s00018-017-2485-1
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
Zheng XFS
中科院分区：
文献类型：
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作者：
Zhang Y;Huang B;Wang HY;Chang A;Zheng XFS
雷帕霉素的机械靶点(MTOR)是一种保守的丝氨酸/苏氨酸激酶，在控制细胞生长和代谢中起着关键作用。MTOR通路的过度激活在人类癌症中很常见，导致肿瘤的不受控制的增殖。MicroRNA(MiRNA)是一类短的非编码RNA，调节着多种基因的表达。MiRNAs的放松管制是癌症的一个标志。最近的研究揭示了miRNAs和mTOR通路在癌症发展过程中的相互作用。这种相互作用似乎提供了对各种细胞功能的微调，并对癌症的行为做出了定性的贡献。本文就miRNAs和mTOR途径之间的相互作用关系：miRNAs对mTOR信号的调控和mTOR对miRNA生物发生的控制进行了综述。这一领域的进一步研究可能对人类癌症的诊断和治疗具有重要意义。
Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR pathway is common in human cancers, driving uncontrolled proliferation. MicroRNA (miRNA) is a class of short noncoding RNAs that regulate the expression of a wide variety of genes. Deregulation of miRNAs is a hallmark of cancer. Recent studies have revealed interplays between miRNAs and the mTOR pathway during cancer development. Such interactions appear to provide a fine-tuning of various cellular functions and contribute qualitatively to the behavior of cancer. Here we provide an overview of current knowledge regarding the reciprocal relationship between miRNAs and mTOR pathway: regulation of mTOR signaling by miRNAs and control of miRNA biogenesis by mTOR. Further research in this area may prove important for the diagnosis and therapy of human cancer.