6-Substituted quinoline-based ratiometric two-photon fluorescent probes for biological Zn2+ detection.
6-Substituted quinoline-based ratiometric two-photon fluorescent probes for biological Zn2+ detection.
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DOI：
10.1039/c2cc30471f
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发表时间：
2012-04
影响因子：
4.9
通讯作者：
Xiangming Meng;Shuxin Wang;Yiming Li;Manzhou Zhu;Q. Guo
中科院分区：
文献类型：
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作者：
Xiangming Meng;Shuxin Wang;Yiming Li;Manzhou Zhu;Q. Guo
以6-取代喹啉为原料，开发了新型比率双光子荧光探针，用于生物Zn（2+）检测。它们对Zn（2+）的结合有很大的红移和很好的比率响应。它们还表现出高的离子选择性和大的双光子吸收截面在近720 nm。由于新的探针是细胞可渗透的，它们可以用于检测双光子激发下的细胞内锌通量。
New ratiometric two-photon fluorescent probes are developed from 6-substituted quinolines for biological Zn(2+) detection. They show large red shifts and good ratiometric responses upon Zn(2+) binding. They also exhibit high ion selectivities and large two-photon absorption cross sections at nearly 720 nm. Because the new probes are cell-permeable, they can be used to detect intracellular zinc flux under two-photon excitation.