Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen.
Unusual type of mitochondrial DNA in mice lacking a maternally transmitted antigen.
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缺乏母源性抗原的小鼠中异常类型的线粒体 DNA。
DOI：
10.1093/nar/11.9.2917
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发表时间：
1983
影响因子：
14.9
通讯作者：
A. Wilson
中科院分区：
文献类型：
--
作者：
S. D. Ferris;U. Ritte;K. Lindahl;E. M. Prager;A. Wilson
细胞表面缺乏母源性抗原 (Mta) 的小鼠具有独特类型的线粒体 DNA。对 25 种抗原状态已知的小鼠的线粒体 DNA 进行限制性分析，可以明显看出这一点。 Mta-小鼠的线粒体 DNA 中已绘制了 168 个切割位点。调查中检测到的其他 8 种线粒体 DNA 的详细图谱也已准备好。据估计，Mta-小鼠与那些表达抗原的小鼠在线粒体基因组中广泛分散的点上有108至141个碱基取代不同。
Mice that lack a maternally transmitted antigen (Mta) on the cell surface share a distinctive type of mitochondrial DNA. This is evident from restriction analyses of mitochondrial DNAs from 25 strains of mice whose antigenic state is known. One hundred sixty-eight cleavage sites have been mapped in the mitochondrial DNA of Mta- mice. Detailed maps for the 8 other types of mitochondrial DNA detected in the survey have also been prepared. The Mta- mice are estimated to differ from those expressing the antigen by 108 to 141 base substitutions at widely scattered points in the mitochondrial genome.