MECHANISMS OF RESPIRATORY TISSUE-INJURY FROM CIGARETTE-SMOKING
MECHANISMS OF RESPIRATORY TISSUE-INJURY FROM CIGARETTE-SMOKING
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DOI：
10.1016/0002-9343(92)90622-i
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发表时间：
1992-07-15
影响因子：
5.9
通讯作者：
MCCUSKER, K
中科院分区：
文献类型：
--
作者：
MCCUSKER, K
吸烟可以被视为一种慢性下呼吸道炎症性疾病。慢性支气管炎和肺气肿是两种主要的肺损伤。慢性支气管炎的特征是慢性粘液高分泌和咳嗽；肺气肿是对肺泡腔的破坏过程。组织损伤可能是由中性粒细胞和单核细胞等炎症细胞产生的降解酶的作用所致。此外，炎症细胞和烟雾中氧化剂的氧化损伤可能参与了这些与吸烟相关的疾病的发病机制。
Cigarette smoking can be viewed as a chronic inflammatory disorder of the lower airways. Two of the major lung injuries that can result are chronic bronchitis and emphysema.Chronic bronchitis is characterized by chronic mucus hypersecretion and cough; emphysema is a destructive process of the alveolar spaces. Tissue injury may result from the actions of degradative enzymes derived from such inflammatory cells as neutrophils and monocytes. In addition, oxidative injury from inflammatory cells and from oxidants in smoke may participate in the pathogenesis of these smoking-related illnesses.