The suprachiasmatic nucleus functions beyond circadian rhythm generation
The suprachiasmatic nucleus functions beyond circadian rhythm generation
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DOI：
10.1016/j.neuroscience.2007.03.058
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发表时间：
2007-11-09
期刊：
影响因子：
3.3
通讯作者：
Shea, S. A.
中科院分区：
文献类型：
--
作者：
Hu, K.;Scheer, F. A. J. L.;Shea, S. A.
我们最近发现，人类活动具有复杂的时间组织，其特征是从几秒到4小时的尺度不变/自相似波动（波动的统计特性在不同的时间尺度上保持不变）。在这里，我们表明，尺度不变的活动模式在人类和大鼠中基本相同，并且存在长达24小时：比以前报道的时间长6倍。从理论上讲，这种尺度不变的模式可以产生一个神经网络的相互作用的控制节点系统组件与反馈回路在不同的时间尺度上运行。然而，这样的控制节点尚未被确定在任何神经生理模型的规模不变性/自相似性哺乳动物。在这里，我们证明了内源性昼夜节律起搏器（视交叉上核; SCN），已知调节运动活动的周期性类似于24小时，也作为一个主要的神经控制节点，负责产生的规模不变的运动模式在广泛的时间范围内，从分钟到至少24小时（而不是仅仅在类似24小时）。值得注意的是，我们发现大鼠SCN损伤完全消除了4至24小时的尺度不变运动模式，并在时间尺度上显著改变了模式
We recently discovered that human activity possesses a complex temporal organization characterized by scale-invariant/self-similar fluctuations from seconds to similar to 4 h(statistical properties of fluctuations remain the same at different time scales). Here, we show that scale-invariant activity patterns are essentially identical in humans and rats, and exist for up to similar to 24 h: six-times longer than previously reported. Theoretically, such scale-invariant patterns can be produced by a neural network of interacting control nodes-system components with feedback loops-operating at different time scales. However such control nodes have not yet been identified in any neurophysiological model of scale invariance/self-similarity in mammals. Here we demonstrate that the endogenous circadian pacemaker (suprachiasmatic nucleus; SCN), known to modulate locomotor activity with a periodicity of similar to 24 h, also acts as a major neural control node responsible for the generation of scale-invariant locomotor patterns over a broad range of time scales from minutes to at least 24 h (rather than solely at similar to 24 h). Remarkably,we found that SCN lesion in rats completely abolished the scale-invariant locomotor patterns between 4 and 24 h and significantly altered the patterns at time scales