Congenital Cutaneous Fibropapillomatosis with No Evidence of Papillomavirus Infection in a Piglet
Congenital Cutaneous Fibropapillomatosis with No Evidence of Papillomavirus Infection in a Piglet
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DOI：
10.1292/jvms.10-0336
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发表时间：
2011-02-01
影响因子：
1.2
通讯作者：
Shirota, Kinji
中科院分区：
文献类型：
--
作者：
Nishiyama, Shoko;Akiba, Yumi;Shirota, Kinji
对一例4月龄仔猪头部和背部皮肤上的多发性黄白色菜花状肿块病变进行了病理学检查。这些病变在断奶期前就已发生。组织学上，皮肤肿瘤的特点是乳头状的结缔组织生长被厚厚的表皮。表皮增生与毛细血管增生、淋巴浆细胞浸润和真皮间质成纤维细胞增生相对应。角质形成细胞内无包涵体，细胞变性明显。免疫组化和聚合酶链反应均未检测到乳头瘤病毒抗原和DNA。因此，本病例的纤维乳头状瘤病可能是错构瘤性的，而不是感染性的。
Multiple yellowish-white, cauliflower-like mass lesions on the skin of the head and back in a 4-month-old piglet were pathologically examined. These lesions had developed before the weaning period. Histologically, the cutaneous neoplasms were characterized by papillary outgrowth of connective tissue covered by thick epidermis. Hyperplasia of the epidermis was corresponded with proliferation of capillaries, lympho-plasmacytic infiltration, and proliferation of fibroblasts in the dermal stroma. There were no inclusion bodies and significant degeneration in the keratinocytes. Papillomavirus antigen and DNA were not detected in these lesions by immunohistochemistry and polymerase chain reaction, respectively. Accordingly, the fibropapillomatosis of the present case might be hamartomatous rather than infectious.