REGIONAL DISTRIBUTION AND RELEASE OF PEPTIDE-YY WITH FATTY-ACIDS OF DIFFERENT CHAIN-LENGTH
REGIONAL DISTRIBUTION AND RELEASE OF PEPTIDE-YY WITH FATTY-ACIDS OF DIFFERENT CHAIN-LENGTH
复制标题
DOI：
10.1152/ajpgi.1985.249.6.g745
复制
发表时间：
1985-12-01
影响因子：
--
通讯作者：
TAYLOR, IL
中科院分区：
文献类型：
--
作者：
APONTE, GW;FINK, AS;TAYLOR, IL
本研究探讨肽YY的区域肠道灌注不同链长的脂肪酸-十二烷酸和油酸。六只狗与慢性胃，十二指肠，空肠瘘进行了研究。将近端灌注液注入十二指肠，并通过放置在十二指肠插管外45 cm处的肠瘘转移。将远端灌注液注入该肠吻合口的尾侧吻合口。比较了肽YY对近端、远端和全肠灌注的反应。近端灌注油酸或十二烷酸未能释放肽YY。相比之下，远端和全肠灌注任一脂肪酸产生了显着的增加，是similar幅度。免疫细胞化学研究表明，犬回结肠粘膜中肽YY细胞占优势，并向相反方向逐渐减少。我们的结论是肽YY释放是不依赖于脂肪酸链的长度和十二指肠不发挥主导作用的肽YY释放。因此，肽YY的释放不同于其表亲胰腺多肽的释放，并且许多肽YY的释放至少部分地由回结肠粘膜中肽YY细胞的直接刺激引起。
The present study examines peptide YY responses to regional intestinal perfusion of fatty acids of different chain length-dodecanoate and oleate. Six dogs with chronic gastric, duodenal, and jejunal fistulas were studied. Proximal perfusates were administered into the duodenum and diverted through an intestinal fistula placed 45 cm beyond the duodenal cannula. Distal perfusates were administered into the caudal stoma of this intestinal stoma. Peptide YY responses to proximal, distal, and whole-gut perfusion were compared. Proximal perfusion with oleate or dodecanoate failed to release peptide YY. In contrast, distal and whole-gut perfusion with either fatty acid produced significant increases that were of similr magnitude. Immunocytochemical studies demonstrated that peptide YY cells predominated in the canine ileocolonic mucosa and decreased progressively in an orad direction. We conclude that peptide YY release is not dependent on fatty acid chain length and that the duodenum does not a play a dominant role in peptide YY release. As such, peptide YY release differs from that of its cousin pancreatic polypeptide and many result at least in part from direct stimulation of the peptide YY cell in the ileocolonic mucosa.