Physical, mechanical, and biocompatibility evaluation of three different types of silicone rubber
Physical, mechanical, and biocompatibility evaluation of three different types of silicone rubber
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DOI：
10.1002/app.11952
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发表时间：
2003-06-06
影响因子：
3
通讯作者：
Khorasani, MT
中科院分区：
文献类型：
--
作者：
Fallahi, D;Mirzadeh, H;Khorasani, MT
硅橡胶作为一种有价值的生物材料在医学上有着广泛的应用，但其表面特性和低润湿性使得长期植入存在严重的问题。本研究采用两种不同的技术对改性硅橡胶的生物相容性进行了评价。将聚丙烯酰胺和硅橡胶的共混物与原始硅酮表面以及经过激光处理的表面进行了比较。使用不同的技术检测了样品的物理和机械性能。硅橡胶的亲水性随水凝胶含量的增加而增加，随激光处理而降低。在体外评估了成纤维细胞（L929）和血小板与这些表面接触的行为。黏附在混合物上的成纤维细胞形态与对照相似。而在激光处理过的表面上，成纤维细胞表现出不同程度的增殖。另一方面，粘附在激光处理表面的血小板比粘附在混合物和未改性的PDMS表面的血小板要少。(C) 2003 Wiley期刊有限公司
Silicone rubber as a valuable biomaterial is widely used in medical applications, but its surface properties and low wettability make serious problems in long-term implants. This work was undertaken to evaluate the biocompatibility of modified silicone rubber using two different techniques. A blend of poly(acrylamide) and silicone rubber was compared with virgin silicone surfaces as well as with those modified by laser treatment. Physical and mechanical properties of the samples were examined using different techniques. The hydrophilicity of the silicone rubber increased with increasing hydrogel content and decreased as a result of laser treatment. Both fibroblast cell (L929) and platelet behavior in contact with these surfaces were evaluated in vitro. The morphology of fibroblast cells that adhered to the blends was similar to the control. In contrast, on the laser-treated surfaces fibroblast cells showed different proliferation. On the other hand, fewer platelets adhered to the laser-treated surface than adhered to the blend and the unmodified PDMS surfaces. (C) 2003 Wiley Periodicals, Inc.