Peritoneal carcinomatosis and lymph node metastasis are prognostic indicators in patients with Borrmann type IV gastric carcinoma.
Peritoneal carcinomatosis and lymph node metastasis are prognostic indicators in patients with Borrmann type IV gastric carcinoma.
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发表时间：
2002-05
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通讯作者：
Chin-Yau Chen;Chew-Wen Wu;S. Lo;M. Hsieh;W. Lui;K. Shen
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作者：
Chin-Yau Chen;Chew-Wen Wu;S. Lo;M. Hsieh;W. Lui;K. Shen
背景/目的观察到 Borrmann IV 型胃癌患者的生存率较低，我们试图确定其预后指标。方法学 总共评估了 103 名 Borrmann IV 型胃癌患者； 604 例 Borrmann I、II 和 III 型患者作为参考。结果Borrmann IV型胃癌体积较大，浸润较深，淋巴管和血管侵犯较多，以弥漫型和硬质间质反应为主，淋巴结广泛转移，腹膜癌变。 5年生存率（11.3%）显着低于其他患者（44.7%，P < 0.001）。生存的单变量和多变量分析表明，腹膜癌转移和淋巴结转移分别与相对风险 1.8 和 1.4 独立相关。无论切除程度如何，46 名具有潜在治愈疾病的患者的生存率相似。结论 腹膜癌转移和淋巴结转移是Borrmann IV型胃癌患者的预后指标。 Borrmann IV 型胃癌的最佳手术策略仍不清楚。
BACKGROUND/AIMS Having observed a lower survival rate of patients with Borrmann type IV gastric cancer, we attempted to determine its prognostic indicators. METHODOLOGY A total of 103 patients with Borrmann type IV gastric cancer were evaluated; 604 patients with Borrmann types I, II and III were used as references. RESULTS The results showed that Borrmann type IV gastric cancer were larger, had deeper invasion, more lymphatic and vascular invasions, predominant diffuse type and scirrhous stromal reaction, extensive lymph node metastases and peritoneal carcinomatosis. The 5-year survival rate (11.3%) was significantly lower than that of others (44.7%, P < 0.001). Univariate and multivariate analyses of survival showed that peritoneal carcinomatosis and lymph node metastasis were independently associated with a relative risk of 1.8 and 1.4, respectively. The survival rates of 46 patients with potential curative disease were similar, regardless of various extents of resection. CONCLUSIONS Peritoneal carcinomatosis and lymph node metastases are prognostic indicators in patients with Borrmann type IV gastric cancer. Optimal surgical strategy for Borrmann type IV gastric cancer remains unclear.