Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
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DOI：
10.1016/j.phymed.2011.10.001
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发表时间：
2012-02-15
期刊：
影响因子：
7.9
通讯作者：
Demirci, Betul
中科院分区：
文献类型：
--
作者：
Can, Ozgur Devrim;Ozkay, Umide Demir;Demirci, Betul
采用行为学方法研究母菊挥发油对小鼠中枢神经系统的影响。采用气相色谱和气相色谱-质谱联用技术分析了水蒸气蒸馏法提取的木姜子挥发油的化学成分。recutita显示α-红没药醇氧化物A（28%）、α-红没药醇氧化物B（17.1%），（Z）-β-法呢烯（15.9%）和α-红没药醇（6.8%）为主要成分（25、50和100 mg/kg）和参比药物咖啡因分别通过活动笼测量和旋转杆试验研究了（25 mg/kg）对小鼠自发运动活动和运动协调的影响。采用旷场、社会互动和高架十字迷宫测试来评估动物的情绪状态。此外，进行悬尾实验以评价MEO对小鼠抑郁水平的影响。结果表明，在50和100 mg/kg，MEO显着增加自发运动活动的数量，在开放领域，高架十字迷宫和社会互动测试中表现出焦虑作用，并减少尾部悬挂试验中动物的不动时间。旋转棒测试中的落球率没有变化。MEO的这种活性特征与典型的精神兴奋剂咖啡因相似。这种兴奋剂样作用的确切作用机制应通过进一步的详细研究来阐明。(C)2011年Elsevier GmbH。All rights reserved.
In this study, the effect of Matricaria recutita L essential oil (MEO) on the central nervous system (CNS) of mice was investigated using some behavioral methods. Chemical profiling both by GC and GC-MS analyses of the hydrodistilled essential oil of M. recutita revealed alpha-bisabolol oxide A (28%), alpha-bisabolol oxide B (17.1%), (Z)-beta-Farnesene (15.9%) and alpha-bisabolol (6.8%) as the main components.Changes induced by MEO (25,50 and 100 mg/kg) and reference drug caffeine (25 mg/kg) in spontaneous locomotor activities and motor coordinations of mice were investigated by activity cage measurements and Rota-Rod tests, respectively. Open field, social interaction and elevated plus-maze tests were applied to assess the emotional state of the animals. Further, tail-suspension test was performed for evaluating the effect of MEO on depression levels of mice. As a result, at 50 and 100 mg/kg, MEO significantly increased the numbers of spontaneous locomotor activities, exhibited anxiogenic effect in the open field, elevated plus-maze and social interaction tests and decreased the immobility times of animals in tail suspension tests. The falling latencies in Rota-Rod tests did not change. This activity profile of MEO was similar to the typical psychostimulant caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies. (C) 2011 Elsevier GmbH. All rights reserved.