EARLY-ONSET DRUG-USE AND RISK OF LATER DRUG PROBLEMS
EARLY-ONSET DRUG-USE AND RISK OF LATER DRUG PROBLEMS
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DOI：
10.1016/0376-8716(95)01194-3
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发表时间：
1995-11-01
影响因子：
4.2
通讯作者：
PETRONIS, KR
中科院分区：
文献类型：
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作者：
ANTHONY, JC;PETRONIS, KR
先前的研究表明，在非法药物使用者中，与非法药物使用开始较早有关的药物滥用或依赖问题的风险增加。这项研究审查了是否可以最好地理解所观察到的关联是一个过程的结果，即早期发病的使用者积累了更多的时间，在此期间，他们可以发展成毒品问题（即，更多的时间，因为第一次非法药物服用）。生存数据分析，调查这个问题，与自我报告的数据，从1525非法药物使用的个人，所有这些人都是18-24岁的参与者在多个地点合作流行病学流域计划。在初次使用非法药物后的第一年，估计的发生药物问题的风险没有明显变化。然而，随着初次使用后约5-7年的过去，估计在青春期前和青春期早期就开始吸毒的青少年出现毒品问题的风险显然更大。因此，先前报告的早发性药物使用和随后的药物问题之间的关系不是时间的假象。这是可能的，药物使用的持续时间应被视为一个“机制”，其中早发性药物使用者经历更大的风险的药物问题，但也有其他的解释，在未来的研究进行调查。
Prior research has suggested that among illicit drug users there is an increased risk of drug abuse or dependence problems associated with earlier onset of illicit drug taking. This study examined whether the observed association might be understood best as the result of a process by which earlier onset users accumulate more time during which they can develop a drug problem (that is, more time since first illicit drug taking). Survival data analysis was employed to investigate this issue, with self-report data from 1525 illicit drug using individuals, all of whom were 18-24-year-oid participants in the multi-site collaborative Epidemiologic Catchment Area Program. In the first year after initial illicit drug use, there was no appreciable variation in the estimated risk of developing a drug problem. However, with passage of some 5-7 years after initial use, the estimated risk of developing drug problems became clearly greater for youths whose drug taking had started during the pre-adolescent and very early adolescent years. The previously reported relationship between early-onset drug use and subsequent drug problems was not, therefore, an artifact of time. It is possible that duration of drug use should be considered as one 'mechanism' by which early-onset drug users experience greater risk of drug problems, but there also are other interpretations to be investigated in future research.