The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population.
The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population.
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DOI：
10.1097/00008571-200111000-00008
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发表时间：
2001-11
期刊：
影响因子：
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通讯作者：
R. Zhai;Geoffrey Liu;Chaomin Yang;Chuonhong Huang;Chuanren Wu;D. Christiani
中科院分区：
文献类型：
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作者：
R. Zhai;Geoffrey Liu;Chaomin Yang;Chuonhong Huang;Chuanren Wu;D. Christiani
白细胞介素-6被认为参与了煤工尘肺的发病过程。最近，已经描述了IL-6基因启动子-174位点的功能性G至C多态性。我们检测了259名广西退休男性（均为退休煤矿工人）的-174位点多态性。结果表明，中国人群中C等位基因的频率低于高加索人群和东印度人群，C等位基因在中国人群中的频率高于高加索人群和东印度人群。
Interleukin-6 is thought to be involved in the pathogenesis of coal workers' pneumoconiosis. Recently, a functional G to C polymorphism at position -174 of the promoter of the IL-6 gene has been described. We examined the -174 polymorphisms in 259 retired Chinese men from Guangxi province (all retired coal miners). Only one GC heterozygous and no CC homozygous variants were found. Our results suggest that the frequency of the C allele in this Chinese population is lower than in Caucasian and east Indian populations.