Association between dietary fiber and serum C-reactive protein
Association between dietary fiber and serum C-reactive protein
复制标题
DOI：
10.1093/ajcn/83.4.760
复制
发表时间：
2006-04-01
影响因子：
7.1
通讯作者：
Ockene, IS
中科院分区：
文献类型：
--
作者：
Ma, YS;Griffith, JA;Ockene, IS
背景：高敏C反应蛋白(CRP)是急性炎症的标志物，最近被认为是未来心血管疾病和糖尿病的独立预测因子。确定影响血清CRP浓度的可改变因素，如饮食，可能为降低这些疾病的风险提供手段。目的：本研究的目的是检验膳食纤维摄入量和CRP之间的纵向关联。设计：数据收集在基线和之后的每个季度(每13周)进行，共5次访问，每次包括身体成分、CRP、饮食和体力活动的测量。结果：共调查524名受试者，有524名受试者进行了多项CRP和膳食因素的测量。平均总膳食纤维摄入量为16.11g/d，平均血清C反应蛋白为1.78 mg/L。横断面和纵向分析发现总膳食纤维摄入量(分别为可溶性纤维和不溶性纤维)与C反应蛋白浓度呈负相关。在总纤维摄入量的最高四分之一的参与者中，CRP浓度升高的可能性比在最低四分之一的参与者低63%(OR：0.37；95%CI：0.16，0.87)。结论：我们的结果表明，膳食纤维对高CRP具有保护作用，这支持了目前对高纤维饮食的推荐。
Background: High sensitivity C-reactive protein (CRP) is a marker of acute inflammation recently recognized as an independent predictor of future cardiovascular disease and diabetes. The identification of modifiable factors, such as diet, that influence serum CRP concentrations may provide the means for reducing the risk of these diseases. Data on longitudinal associations between dietary fiber intake and CRP are currently lacking.Objective: The purpose of this study was to examine longitudinal associations between dietary fiber intake and CRP.Design: Data collection took place at baseline and quarterly (every 13 wk) thereafter for a total of 5 visits, each including measurements of body composition, CRP, diet, and physical activity. Relations between serum CRP and dietary fiber were assessed by using linear mixed models and logistic regression, adjusted for covariates.Results: A total of 524 subjects had multiple measurements of CRP and dietary factors. The average total dietary fiber intake was 16.11 g/d. Average serum CRP was 1.78 mg/L. We observed an inverse association between intake of total dietary fiber (separately for soluble and insoluble fiber) and CRP concentrations in both cross-sectional and longitudinal analyses. The likelihood of elevated CRP concentrations was 63% lower (OR: 0.37; 95% Cl: 0.16, 0.87) in participants in the highest quartile of total fiber intake than in participants in the lowest quartile.Conclusions: Our results suggest that dietary fiber is protective against high CRP, which supports current recommendations for a diet high in fiber.