Right hemisphere semantic processing of visual words in an aphasic patient: An fMRI study
Right hemisphere semantic processing of visual words in an aphasic patient: An fMRI study
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DOI：
10.1006/brln.2000.2317
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发表时间：
2000-07-01
影响因子：
2.5
通讯作者：
Kertesz, A
中科院分区：
文献类型：
--
作者：
Gold, BT;Kertesz, A
本研究旨在确定支持左半球 (LH) 语言结构大规模损伤的患者视觉单词语义处理的神经网络。患者 GP 和对照受试者 RT 执行语义和拼写任务，同时使用功能磁共振成像记录大脑激活模式。在 RT 中，语义-正字法比较激活了 LH 外侧裂和外侧颞区，与其他语义辨别神经影像学研究中非脑损伤受试者激活的区域网络相当。在 GP 中，相同的比较激活了同源的右半球区域，证明了右半球促进视觉词汇语义过程的能力。结果是在正常右半球视觉单词语义处理能力的背景下讨论的。在先天半球能力的背景下检查功能性神经影像学研究的结果可能有助于调和有关支持失语症恢复机制的不同主张。 (C) 2000 年学术出版社。
This study was designed to identify the neural network supporting the semantic processing of visual words in a patient with large-scale damage to left-hemisphere (LH) language structures. Patient GP, and a control subject, RT, performed semantic and orthographic tasks while brain-activation patterns were recorded using functional magnetic resonance imaging. In RT, the semantic-orthographic comparison activated LH perisylvian and extrasylvian temporal regions comparable to the network of areas activated by non-brain-damaged subjects in other neuroimaging studies of semantic discrimination. In GP, the same comparison activated homologous right-hemisphere regions, demonstrating the ability of the right hemisphere to subserve visual lexicosemantic processes. The results are discussed within the context of the normal right hemisphere's capacity for semantic processing of visual words. Examining results from functional neuroimaging studies on recovery in the context of innate hemispheric abilities may enable reconciliation of disparate claims about mechanisms supporting recovery from aphasia. (C) 2000 Academic Press.