Characteristics of treatment-na?ve quiescent choroidal neovascularization detected by optical coherence tomography angiography in patients with age-related macular degeneration
Characteristics of treatment-na?ve quiescent choroidal neovascularization detected by optical coherence tomography angiography in patients with age-related macular degeneration
复制标题
光学相干断层扫描血管造影检测年龄相关性黄斑变性患者初治静态脉络膜新生血管特征
DOI：
10.1007/s00417-021-05127-x
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Iida Tomohiro
中科院分区：
文献类型：
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作者：
Fukushima Akira;Maruko Ichiro;Chujo Kyoko;Hasegawa Taiji;Arakawa Hisaya;Iida Tomohiro
目的确定光学相干断层扫描血管造影 (OCTA) 检测到的初治静态脉络膜新生血管 (CNV) 眼睛的特征。方法对 37 例初治连续患者（30 名男性，7 名女性，平均 69.8 岁）的 38 只眼睛进行研究。通过 OCTA (RTVue XR Avanti, Optovue, Fremont, CA) 在所有眼睛中检测到静态 CNV。扫频 OCT（SS-OCT；DRI-OCT，Topcon，日本）证实不存在渗出。对症状、视力、CNV 大小和对侧眼睛的状态进行了评估。对患者进行纵向随访，并记录每位患者的随访时间长度和渗出情况。我们还调查了患者转诊医院的医疗记录，以查找先前的渗出情况。结果所有患有静态 CNV 的眼睛在初次就诊时均通过 OCT 和 OCTA 图像诊断为视网膜色素上皮下 CNV，即 1 型 CNV。根据转诊医院的医疗记录，15 只眼睛 (39.5%) 确认之前有渗出。 18 只眼睛 (47.3%) 出现症状。 12 只眼睛中出现渗出性 CNV。在平均 25.1 个月的随访期间，12 只眼睛 (31.6%) 出现渗出。一半的眼睛先前有渗出液。随访期间出现渗出的眼睛的基线 CNV 大于无渗出的眼睛；然而，差异并不显着（0.59±0.47 vs 0.48±0.32 mm2，P= 0.50）。 结论 在平均 2 年随访期间，大约 30% 的眼睛会出现静态 CNV 渗出。在研究静态 CNV 时，必须记住这些发现，因为静态 CNV 无法与以前活跃 CNV 和自然失活 CNV 的眼睛区分开来。
PurposeTo determine the characteristics of eyes with treatment-naïve quiescent choroidal neovascularization (CNV) detected by optical coherence tomography angiography (OCTA).MethodsThirty-eight eyes of 37 treatment-naïve consecutive patients (30 men, 7 women, average 69.8 years) were studied. Quiescent CNVs were detected by OCTA (RTVue XR Avanti, Optovue, Fremont, CA) in all eyes. Swept-source OCT (SS-OCT; DRI-OCT, Topcon, Japan) confirmed the absence of exudation. The symptoms, visual acuity, CNV size, and status of the fellow eye were evaluated. Patients were followed longitudinally and the length of follow-up period and development of exudation were recorded for each patient. We also investigated patients’ medical records from their referral hospitals in search of prior exudation.ResultsAll eyes with quiescent CNV were diagnosed at the initial visit with sub-retinal pigment epithelium CNVs, i.e., type 1 CNV, from the OCT and OCTA images. Prior exudation was confirmed in 15 eyes (39.5%) from their medical records of the referral hospitals. Symptoms were present in 18 eyes (47.3%). An exudative CNV was present in 12 of the fellow eyes. Exudation developed in 12 eyes (31.6%) during an average follow-up period of 25.1 months. One-half of the eyes had a prior exudation. The CNV at the baseline in eyes that developed exudation during the follow-up period was larger than eyes without exudation; however, the difference was not significant (0.59±0.47 vs 0.48±0.32 mm2,P= 0.50).ConclusionQuiescent CNVs will develop exudation in approximately 30% of the eyes during a mean 2-year follow-up period. These findings must be remembered when investigating quiescent CNVs that could not be distinguished from eyes with former active CNV and naturally deactivate CNV.