PERFUSION IMAGING
PERFUSION IMAGING
复制标题
DOI：
10.1002/mrm.1910230106
复制
发表时间：
1992-01-01
影响因子：
3.3
通讯作者：
KORETSKY, AP
中科院分区：
文献类型：
--
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
组织灌注的测量对于体内器官的功能评估非常重要。在这里，我们报告使用 1 H NMR 成像在 4.7 T 下生成大鼠大脑中的灌注图。通过切片选择性饱和成像序列，流向大脑的血液在颈部区域饱和，以近端饱和自旋的形式创建内源性示踪剂。由于质子 T1 时间相对较长，特别是在高场强下，饱和自旋与大脑中的大量水交换，并形成稳态，其中饱和自旋的区域浓度由局部血流和局部 T1 决定。在脑外等距施加的远端饱和用作饱和脉冲效果的控制。氟烷麻醉下正常碳酸血症大鼠大脑的平均脑血流量确定为 105 ± 16 cc。 100 g−1。 min−1（平均值±SEM，n = 3），与文献中报告的值非常一致，并且对动脉二氧化碳浓度的增加敏感。该技术允许以 1H MRI 的分辨率无创地测量区域灌注图，并且应该很容易应用于人体研究。 © 1992 学术出版社
Measurement of tissue perfusion is important for the functional assessment of organsin vivo.Here we report the use of1H NMR imaging to generate perfusion maps in the rat brain at 4.7 T. Blood water flowing to the brain is saturated in the neck region with a sliceselective saturation imaging sequence, creating an endogenous tracer in the form of proximally saturated spins. Because proton T1times are relatively long, particularly at high field strengths, saturated spins exchange with bulk water in the brain and a steady state is created where the regional concentration of saturated spins is determined by the regional blood flow and regional T1. Distal saturation applied equidistantly outside the brain serves as a control for effects of the saturation pulses. Average cerebral blood flow in normocapnic rat brain under halothane anesthesia was determined to be 105 ± 16 cc. 100 g−1. min−1(mean ± SEM,n= 3), in good agreement with values reported in the literature, and was sensitive to increases in arterialpCO2. This technique allows regional perfusion maps to be measured noninvasively, with the resolution of1H MRI, and should be readily applicable to human studies. © 1992 Academic Press, Inc.