Quantitative analysis of the age-related fragmentation of hamster 24-h activity rhythms
Quantitative analysis of the age-related fragmentation of hamster 24-h activity rhythms
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DOI：
10.1152/ajpregu.1997.273.6.r2132
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发表时间：
1997-12-01
影响因子：
2.8
通讯作者：
Turek, FW
中科院分区：
文献类型：
--
作者：
Penev, PD;Zee, PC;Turek, FW
自发活动的连续监测已成为啮齿动物昼夜节律研究中应用最广泛的指标之一。这种行为测量对于描述衰老对昼夜节律的影响也是非常有用的。本研究描述了成功地使用原木生存方法来识别仓鼠轮子跑活动的离散回合，并详细描述了这一行为变量的24小时曲线中与年龄相关的碎片。此外，逐步判别分析确定了区分幼龄(3个月)和老年(17-18个月)金黄地鼠跑轮活动的个体模式的最重要的量化指标。结果表明，该方法可用于研究影响啮齿动物运动行为时序控制的遗传、发育、神经化学、生理和环境因素。
The continuous monitoring of spontaneous locomotor activity has emerged as one of the most widely used metrics in rodent circadian research. This behavioral measure is also extremely useful for the description of the effects of aging on circadian rhythms. The present study describes the successful use of a log-survivorship approach to identify discrete bouts of hamster wheel-running activity and provides a detailed description of the age-related fragmentation in the 24-h profile of this behavioral variable. In addition, stepwise discriminant analysis identified the most important quantitative measures for distinguishing between the individual patterns of wheel-running activity of young (3 mo) and old (17-18 mo) golden hamsters. The results suggest that this method of bout analysis can be a valuable tool for the study of genetic, developmental, neurochemical, physiological, and environmental factors involved in the temporal control of rodent locomotor behavior.