CORRELATIONS BETWEEN ESTROGEN-RECEPTOR, PROGESTERONE-RECEPTOR, AND PATIENT CHARACTERISTICS IN HUMAN-BREAST CANCER
CORRELATIONS BETWEEN ESTROGEN-RECEPTOR, PROGESTERONE-RECEPTOR, AND PATIENT CHARACTERISTICS IN HUMAN-BREAST CANCER
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DOI：
10.1200/jco.1984.2.10.1102
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发表时间：
1984-01-01
影响因子：
45.3
通讯作者：
MCGUIRE, WL
中科院分区：
文献类型：
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作者：
CLARK, GM;OSBORNE, CK;MCGUIRE, WL
雌激素受体(ER)状态的测定已成为乳腺癌治疗的标准做法。对2977例原发性乳腺癌患者的雌激素受体、孕激素受体和各种患者特征之间的关系进行了描述。老年女性比年轻女性更有可能是雌激素受体阳性。当将患者的年龄和绝经状态放在一起分析时，年龄是雌激素受体浓度升高的主要决定因素。当单独分析这些变量时，年龄或绝经状态与孕激素受体似乎没有关系。但在比较相同年龄的患者时，绝经前女性的孕激素受体浓度高于绝经后女性，这可能反映了雌激素介导的孕激素受体合成更多。肿瘤大小与激素受体浓度呈负相关，而激素受体与腋窝淋巴结阳性数和原发肿瘤的位置无关。
Determination of estrogen-receptor (ER) status has become a standard practice in the treatment of breast cancer. The relationships between estrogen receptor, progesterone receptor, and a variety of patient characteristics are described for 2977 women with primary breast cancer. Older women were more likely to be estrogen-receptor positive than younger women. When patient age and menopausal status were analyzed together, age was the primary determinant of increased estrogen-receptor concentrations. There appeared to be no relationship with progesterone receptor for either age or menopausal status when these variables were analyzed separately. But premenopausal women had higher progesterone receptor concentrations than postmenopausal women when patients of the same age were compared, perhaps reflecting greater estrogen-mediated synthesis of progesterone receptor. Tumor size was negatively related to steroid receptor concentration, but no relationships were observed between steroid receptors and either the number of positive axillary lymph nodes or the location of the primary tumor.