In vitro evaluation of transdermal permeation effects of Fu’s cupping therapy via six diffusion kinetics models
In vitro evaluation of transdermal permeation effects of Fu’s cupping therapy via six diffusion kinetics models
复制标题
通过六种扩散动力学模型体外评价福氏拔罐疗法的透皮渗透效果
DOI：
10.12032/tmr201915098
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发表时间：
2019-01
影响因子：
1.3
通讯作者：
Xiao-Bo Sun
中科院分区：
文献类型：
--
作者：
Wei-Jie Xie;Yu-Mei Wu;Shuai-Shuai Chen;Jian Xu;Fang-Fang Yang;Yong-Ping Zhang;Xiao-Bo Sun
本研究建立了吲哚美辛亲水凝胶贴剂体外透皮释放的6种动力学模型，包括零级动力学方程、一级动力学方程、Higuchi-级动力学方程、Ritger-Peppas动力学方程、Weibull动力学方程和Hixcon-Crowell动力学方程。以3%和5%月桂氮卓酮等化学促渗剂及离子导入法为对照。体外透皮扩散试验和吲哚美辛定量高效液相色谱系统进行。经Higuchi和Weibull动力学方程的透皮参数，表明傅氏拔罐疗法能显著改善Higuchi和Weibull体外透皮动力学参数，提高透皮速率和渗透系数，缩短滞后时间。此外，统计学分析推测，治疗46 h后皮肤屏障功能可恢复。因此，FCT作为一种新的物理经皮给药技术，其经皮渗透效果明显，具有中医药的特点，具有重要的临床应用价值。
In this study, six kinetics models of indomethacin hydrophilic gel patch transdermal in vitro release was established, including zero-level, first-order, Higuchi-level, Ritger-Peppas, Weibull and Hixcon-Crowell dynamic equations. The chemical permeation enhancers, including 3% and 5% Azone, and iontophoresis were used as the control. Transdermal diffusion tests were performed in vitro and indomethacin was quantified by high performance liquid chromatography system. The transdermal parameter of the Higuchi and Weibull dynamic equations, indicated that Fu’s cupping therapy (FCT) could significantly improve Higuchi and Weibull kinetic parameters in vitro transdermal, increased transdermal rate and permeability coefficient, reduced lagging time. Additionally, statistical analysis speculated the skin barrier function could be restored after 46 h treatment. Hence, as a new physical transdermal drug delivery technology, transdermal permeation effects produced by FCT are obvious, which has the characteristics of traditional Chinese medicine and has important clinical application value.