Autoreactive CD8 T cells in organ-specific autoimmunity: Emerging targets for therapeutic intervention
Autoreactive CD8 T cells in organ-specific autoimmunity: Emerging targets for therapeutic intervention
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DOI：
10.1016/s1074-7613(02)00338-2
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发表时间：
2002-07-01
期刊：
影响因子：
32.4
通讯作者：
Santamaria, P
中科院分区：
文献类型：
--
作者：
Liblau, RS;Wong, FS;Santamaria, P
CD8 T细胞在器官特异性自身免疫性疾病发病机制中的重要性以前没有得到很好的认识。然而，最近的证据表明，自身反应性CD8 T细胞可以在很大程度上促进鼠和人自身免疫性疾病的组织损伤。因此，这些T细胞现在成为治疗干预的有吸引力的靶点。
The importance of CD8 T cells in the pathogenesis of organ-specific autoimmune diseases has not previously been well recognized. Recent evidence, however, indicates that autoreactive CD8 T cells can contribute substantially to tissue damage in both murine and human autoimmune disorders. As such, these T cells now become an attractive target for therapeutic intervention.