Early Persistent Blood Eosinophilia in Necrotizing Enterocolitis Is a Predictor of Late Complications.
Early Persistent Blood Eosinophilia in Necrotizing Enterocolitis Is a Predictor of Late Complications.
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DOI：
10.1159/000431305
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发表时间：
2015
期刊：
影响因子：
2.5
通讯作者：
Sherman MP
中科院分区：
文献类型：
--
作者：
Wahidi LS;Sherman J;Miller MM;Zaghouani H;Sherman MP
Eosinophils infiltrate into intestinal tissue during necrotizing enterocolitis (NEC) and adult bowel diseases. We theorized that epithelial damage causes eosinophilic activation and recruitment during NEC onset. We studied the relationship between persistent blood eosinophilia and medical or surgical complications during NEC. NEC cases and controls at MU Children's Hospital (2008 - 2013) underwent review. A Likert scale measured the severity of NEC severity. We utilized a SPSS database for statistical analyses. Among 50 cases with NEC, Group 1 infants (n = 15) had eosinophilia at less than two days after onset; Group 2 had NEC but no persistent eosinophilia (n = 25). Control infants without NEC were matched for birth weight and gestational age (Group 3, n = 46). Group 4 included four preterm infants with infection and ≤ 5 days of eosinophilia. Hematologic assessment defined persistent eosinophilia as ≥ 5% eosinophils for ≥ 5 days after NEC onset. Absolute eosinophil counts were 2 times as high in Group 1 versus Group 2 (p = .002). Group 1 had a mean duration of eosinophilia of 8 days versus one day in Group 2 (p<.001). A Likert score of NEC severity was 3-fold higher in Group 1 versus Group 2 (p<.001). Compared to Group 2, Group 1 infants were 8 times more likely to have hepatic fibrosis or intestinal strictures. Early persistent blood eosinophilia is not currently a predictor of complications after the onset of NEC. This biomarker identifies immature infants at high risk for adverse outcomes during NEC convalescence.
