Attention-deficit and hyperactive neurobehavioural characteristics induced by perinatal hypothyroidism in rats
Attention-deficit and hyperactive neurobehavioural characteristics induced by perinatal hypothyroidism in rats
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DOI：
10.1016/j.bbr.2004.11.012
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发表时间：
2005-04-30
影响因子：
2.7
通讯作者：
Yoshikawa, Y
中科院分区：
文献类型：
--
作者：
Negishi, T;Kawasaki, K;Yoshikawa, Y
甲状腺激素对于哺乳动物中枢神经系统（CNS）的正常发育至关重要。在本研究中，我们检查了抗甲状腺药物丙硫氧嘧啶（PTU）引起的短暂围产期甲状腺功能减退症引起的行为改变。这种药物会对围产期甲状腺系统造成干扰，并导致随后的行为改变，我们使用一系列行为测试进行了研究，并特别关注注意力缺陷/多动障碍 (ADHD) 类行为。在旷场测试中，经历过围产期甲状腺功能减退症（HT 大鼠）的雄性和雌性大鼠均表现出运动行为百分比增加和梳理行为减少，这表明 HT 大鼠可能过度活跃且表现出较少的焦虑特征。雄性和雌性 HT 大鼠在被动回避测试中均未表现出保留。在主动回避测试的早期阶段，雄性 HT 大鼠的正确回避反应率明显低于对照大鼠。此外，我们观察到HT大鼠在试验间隔期间穿过隔板的次数以及在5秒电刺激期间回避失败的百分比显着增加，这表明HT大鼠焦躁不安，注意力持续时间缩短并且容易惊慌。在测量黑暗时期的自发运动活动时，雄性 HT 大鼠似乎以短而快的步伐进入活跃阶段，而雄性对照大鼠在无压力的黑暗时期仅表现出较长的活跃阶段。 HT 大鼠的这些异常行为特征可能与某些 ADHD 病例中发现的一致。 (c) 2004 Elsevier B.V. 保留所有权利。
Thyroid hormone is essential for the proper development of the mammalian central nervous system (CNS). In the present study, we examined behavioural alterations caused by transient perinatal hypothyroidism induced by an anti-thyroid drug, propylthiouracil (PTU). This drug produces perinatal disruption of the thyroid system and subsequent behavioural changes, which we investigated using a series of behavioural tests and focusing particularly on attention-deficit/hyperactivity disorder (ADHD)-like behaviours. In the open field test, both male and female rats that had experienced perinatal hypothyroidism (HT rats) showed an increased percent of locomotion behaviour and reduced grooming behaviour, suggesting that HT rats may be hyperactive and show fewer anxiety characteristics. Neither male nor female HT rats showed retention in the passive avoidance test. Male HT rats showed a significantly lower rate of correct avoidance responses than control rats in earlier sessions in the active avoidance test. In addition, we observed significant increases in the number of times that rats crossed the partition during inter-trial intervals and the percent of failure of avoidance during 5 s electrical stimuli in HT rats, suggesting that HT rats are restless, have a shortened attention span and panic easily. In measuring spontaneous motor activity during a period of darkness, male HT rats appeared to plunge into active phase with short, quick steps, while male control rats showed only long active phases during a stress-free period of darkness. These abnormal behavioural characteristics in HT rats might coincide with those found in some cases of ADHD. (c) 2004 Elsevier B.V. All rights reserved.