Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease.
Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease.
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DOI：
10.1371/journal.pone.0182217
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Oda MN
中科院分区：
文献类型：
--
作者：
Borja MS;Hammerson B;Tang C;Savinova OV;Shearer GC;Oda MN
我们测试了一种假设，即代谢综合征(MetSyn)患者没有糖尿病和心血管疾病的症状，高密度脂蛋白(HDL)-载脂蛋白A-I交换(HAE)是衡量高密度脂蛋白(HDL)功能的指标，也是反向胆固醇运输(RCT)的关键步骤。我们还比较了HAE和基于细胞的胆固醇流出能力(CEC)，以解决先前关于CEC在MetSyn人群中增强的报道。测定60例MetSyn患者和14例正常对照组的HAE和ABCA1特异性CEC，作为高密度脂蛋白功能的检测指标。使用MetSyn和CVD风险的临床标记物，采用多元线性回归模型对HAE和CEC的预测因素进行评估。Metsyn患者HAE显著降低(49.0±10.9%vs.61.2±6.1%，P<；0.0001)，ABCA1特异性CEC显著降低(10.1±1.6%vs.12.3±2.0%，P<；0.002)。多元线性回归分析显示载脂蛋白A-I浓度是高脂血症发生的显著正向预测因子，每mg/dL载脂蛋白A-I的高脂血症发生率显著降低(P=0.004)。MetSyn状态是CEC的负预测因子，而甘油三酯(TG)是CEC的正预测因子，MetSyn患者每mg/dL TG的CEC高于对照组，但总体CEC低于对照组。MetSyn患者HAE受损，导致ABCA1介导的CEC能力降低。MetSyn状态与CEC呈负相关，而与TG呈正相关，这解释了早期MetSyn研究集中在CEC的相互矛盾的结果。在广泛的载脂蛋白A-I和高密度脂蛋白颗粒绝对值范围内，MetSyn患者的HAE和CEC受到抑制，支持这一观察结果，即这一患者群体承担着显著的残余心血管疾病风险。
We tested the hypothesis that HDL-apolipoprotein A-I exchange (HAE), a measure of high-density lipoprotein (HDL) function and a key step in reverse cholesterol transport (RCT), is impaired in metabolic syndrome (MetSyn) patients who are asymptomatic for diabetes and cardiovascular disease. We also compared HAE with cell-based cholesterol efflux capacity (CEC) to address previous reports that CEC is enhanced in MetSyn populations. HAE and ABCA1-specific CEC were measured as tests of HDL function in 60 MetSyn patients and 14 normolipidemic control subjects. Predictors of HAE and CEC were evaluated with multiple linear regression modeling using clinical markers of MetSyn and CVD risk. HAE was significantly reduced in MetSyn patients (49.0 ± 10.9% vs. 61.2 ± 6.1%, P < 0.0001), as was ABCA1-specific CEC (10.1 ± 1.6% vs. 12.3 ± 2.0%, P < 0.002). Multiple linear regression analysis identified apoA-I concentration as a significant positive predictor of HAE, and MetSyn patients had significantly lower HAE per mg/dL of apoA-I (P = 0.004). MetSyn status was a negative predictor of CEC, but triglyceride (TG) was a positive predictor of CEC, with MetSyn patients having higher CEC per mg/dL of TG, but lower overall CEC compared to controls. MetSyn patients have impaired HAE that contributes to reduced capacity for ABCA1-mediated CEC. MetSyn status is inversely correlated with CEC but positively correlated with TG, which explains the contradictory results from earlier MetSyn studies focused on CEC. HAE and CEC are inhibited in MetSyn patients over a broad range of absolute apoA-I and HDL particle levels, supporting the observation that this patient population bears significant residual cardiovascular disease risk.
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影响因子：
6.5
作者：
Meikle PJ;Wong G;Tan R;Giral P;Robillard P;Orsoni A;Hounslow N;Magliano DJ;Shaw JE;Curran JE;Blangero J;Kingwell BA;Chapman MJ
通讯作者：
Chapman MJ
影响因子：
158.5
作者：
Barter, Philip;Gotto, Antonio M.;Fruchart, Jean-Charles
通讯作者：
Fruchart, Jean-Charles
影响因子：
5.3
作者：
de Souza, Juliana A.;Vindis, Cecile;Kontush, Anatol
通讯作者：
Kontush, Anatol
影响因子：
4.8
作者：
Cavigiolio, Giorgio;Geier, Ethan G.;Oda, Michael N.
通讯作者：
Oda, Michael N.
DOI：
10.1161/atvbaha.109.199158
发表时间：
2010-04
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
de la Llera-Moya M;Drazul-Schrader D;Asztalos BF;Cuchel M;Rader DJ;Rothblat GH
通讯作者：
Rothblat GH