Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis
Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis
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DOI：
10.1212/wnl.0b013e3181b59c40
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发表时间：
2009-09-01
期刊：
影响因子：
9.9
通讯作者：
Alfredsson, Lars
中科院分区：
文献类型：
--
作者：
Hedstrom, Anna K.;Baarnhielm, Maria;Alfredsson, Lars
目的：本研究的目的是估计吸烟和瑞典鼻烟使用对发展为多发性硬化症（MS）的风险的影响。方法：在瑞典进行了一项以人群为基础的病例对照研究，使用MS的事件病例（902例和1,855例对照）。病例定义为研究基地中接受MS诊断的受试者，对照组从研究基地中随机选择。将吸烟者与从不吸烟者的MS发病率进行比较。我们还调查了使用瑞典鼻烟是否对MS的发病风险有影响。结果：男女吸烟者患MS的风险增加（女性OR 1.4，95%置信区间CI 1.2-1.7，男性OR 1.8，95% CI 1.3-2.5）。即使在以前中度吸烟的受试者中，风险也明显增加（
Objective: The aim of this study was to estimate the influence of tobacco smoking and Swedish snuff use on the risk of developing multiple sclerosis (MS).Methods: A population-based case-control study was performed in Sweden, using incident cases of MS (902 cases and 1,855 controls). A case was defined as a subject from the study base who had received a diagnosis of MS, and controls were randomly selected from the study base. The incidence of MS among smokers was compared with that of never-smokers. We also investigated whether the use of Swedish snuff had an impact on the risk of developing MS.Results: Smokers of both sexes had an increased risk of developing MS (odds ratio [OR] 1.4, 95% confidence interval [CI] 1.2-1.7 for women, and OR 1.8, 95% CI 1.3-2.5 for men). The increased risk was apparent even among subjects who had previously smoked moderately (