Shear-wave elastography of invasive breast cancer: correlation between quantitative mean elasticity value and immunohistochemical profile
Shear-wave elastography of invasive breast cancer: correlation between quantitative mean elasticity value and immunohistochemical profile
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DOI：
10.1007/s10549-013-2407-3
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发表时间：
2013-02-01
影响因子：
3.8
通讯作者：
Jeong, Joon
中科院分区：
文献类型：
--
作者：
Youk, Ji Hyun;Gweon, Hye Mi;Jeong, Joon
比较剪切波弹性成像（SWE）测量的平均弹性值与浸润性乳腺癌的免疫组化图谱。这是一项机构审查委员会批准的回顾性研究，豁免知情同意。共纳入152名接受术前SWE和手术的女性中的166例浸润性乳腺癌。使用SWE测量每个病变的定量平均弹性值（kPa）。回顾病历以确定可触知性、浸润性大小、淋巴管浸润、组织学分级和腋窝淋巴结状态。基于免疫组织化学谱，肿瘤亚型被分类为三阴性（TN）、管腔A和B或人表皮生长因子受体2富集癌。采用单因素回归模型和多因素线性回归分析，将平均弹性值与临床病理特征进行相关分析。触诊（P < 0.0001）、较大的体积（P = 0.013）、淋巴管侵犯（P < 0.0001）、较高的组织学分级（P < 0.0001）和淋巴结受累（P = 0.018）与平均弹性值显著相关。在免疫组化和肿瘤亚型中，雌激素受体（P = 0.015）、孕激素受体（P = 0.002）、Ki-67（P = 0.009）和TN（P = 0.009）肿瘤亚型与平均弹性值相关。多因素Logistic回归分析显示，以下变量与平均弹性值显著相关：可触及异常，组织学分级和淋巴管浸润。没有免疫组化的癌症是独立相关的平均弹性值。对于浸润性乳腺癌，预后不良的临床病理特征表现出较高的平均弹性值比预后良好。然而，免疫组化的配置文件显示没有独立的关联与平均弹性值。
To compare the mean elasticity value, as measured by shear-wave elastography (SWE), with immunohistochemical profile of invasive breast cancer. This was an institutional review board-approved retrospective study, with a waiver of informed consent. A total of 166 invasive breast cancers in 152 women undergoing preoperative SWE and surgery were included. Quantitative mean elasticity values in kPa were measured for each lesion by using SWE. Medical records were reviewed to determine palpability, invasive size, lymphovascular invasion, histologic grade, and axillary lymph node status. Based on the immunohistochemical profiles, tumor subtypes were categorized as triple-negative (TN), luminal A and B, or human epidermal growth factor receptor 2-enriched cancer. The mean elasticity value was correlated with clinicopathological features using univariate regression models and multivariate linear regression analysis. Palpability (P < 0.0001), larger size (P = 0.013), lymphovascular invasion (P < 0.0001), higher histologic grade (P < 0.0001), and lymph node involvement (P = 0.018) were significantly associated with the mean elasticity value. For the immunohistochemical profiles and tumor subtypes, the estrogen receptor (P = 0.015), progesterone receptor (P = 0.002), Ki-67 (P = 0.009), and the TN (P = 0.009) tumor subtype were correlated with the mean elasticity value. Multivariate logistic regression analysis showed that the following variables were significantly associated with the mean elasticity value: palpable abnormality, histologic grade, and lymphovascular invasion. No immunohistochemical profile of the cancers was independently correlated with the mean elasticity value. For invasive breast cancers, clinicopathological features of poor prognosis showed higher mean elasticity values than those of good prognosis. However, the immunohistochemical profile showed no independent association with the mean elasticity value.