Opioid-Induced Cardioprotection against Ischemia-Reperfusion Injury: The Challenge in Diabetes
Opioid-Induced Cardioprotection against Ischemia-Reperfusion Injury: The Challenge in Diabetes
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DOI：
10.4172/2155-6156.1000616
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
S. Lei;Wating Su;R. Xue;Hui-Min Liu;Liangqing Zhang;Hui-lai Miao;Youtan Liu;Haobo Li;M. Irwin;Z. Xia
中科院分区：
文献类型：
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作者：
S. Lei;Wating Su;R. Xue;Hui-Min Liu;Liangqing Zhang;Hui-lai Miao;Youtan Liu;Haobo Li;M. Irwin;Z. Xia
缺血性心脏病是糖尿病发病率和死亡率的主要原因。糖尿病患者围手术期心肌梗死的风险特别高，对心肌缺血再灌注损伤（IRI）的抵抗力较低，但其潜在机制尚不清楚。阿片类药物预处理已被充分证明对心肌IRI具有保护作用，如缺血预处理，但这种作用在糖尿病条件下受到损害，并且对阿片类药物诱导的糖尿病期间心脏保护作用知之甚少。这篇简短的综述总结了我们目前对糖尿病对阿片类药物诱导的心肌IRI保护作用的认识，以及阿片类药物在糖尿病心脏中限制IRI的挑战。
Ischemic heart disease is the leading cause of morbidity and mortality in diabetes. Patients with diabetes are particularly at risk of perioperative myocardial infarction, and are less resistant to myocardial ischemia-reperfusion injury (IRI), but the underlying mechanisms are very unclear. Opioid conditioning has been well demonstrated to be protective against myocardial IRI like ischemic conditioning, but this effect is compromised in diabetic condition, and little is known about the role of opioid-induced cardioprotection during diabetes. This brief review is to provide a summary of our present understanding of the effects of diabetes on opioids induced protection against myocardial IRI and the challenges of limiting IRI by opioids in the diabetic heart .