REGIONAL-DEVELOPMENT OF THE HUMAN-EPIDERMIS IN THE 1ST TRIMESTER EMBRYO AND THE 2ND TRIMESTER FETUS (AGES RELATED TO THE TIMING OF AMNIOCENTESIS AND FETAL BIOPSY)
REGIONAL-DEVELOPMENT OF THE HUMAN-EPIDERMIS IN THE 1ST TRIMESTER EMBRYO AND THE 2ND TRIMESTER FETUS (AGES RELATED TO THE TIMING OF AMNIOCENTESIS AND FETAL BIOPSY)
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DOI：
10.1111/1523-1747.ep12535062
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发表时间：
1980-01-01
影响因子：
6.5
通讯作者：
ODLAND, GF
中科院分区：
文献类型：
--
作者：
HOLBROOK, KA;ODLAND, GF
表皮从多个身体部位的整个人类胚胎和胎儿的45和65天，16和21周估计孕龄，以确定是否存在区域依赖性，可变率的滤泡间表皮发育。表皮的表面特征和厚度分别通过扫描电子显微镜和光学显微镜进行评价。所有的表皮发育同时进行，在第一个三个月的脚是更先进的厚度和分化状态除外。在第二孕期，头部和足部的表皮表现出更早熟的发展，特别是在有关的特殊感觉器官和足底表面。大部分身体的毛囊间表皮在发育状态下大致相当。这些数据具有潜在的相关性，产前诊断遗传性皮肤病从羊膜穿刺术和/或胎儿活检标本;调查的总表皮表面允许预测类型的皮肤来源的细胞，应存在于羊水中在给定的年龄，允许评估胎儿活检从1个区域，并允许信心，它是一个准确的指标胎儿皮肤发育，年龄和状态一般。
The epidermis was sampled from multiple body sites of whole human embryos and fetuses of 45 and 65 days, 16 and 21 wk estimated gestation age to determine whether a regionally dependent, variable rate of interfollicular epidermal development exists. Surface characteristics and thickness of the epidermis were evaluated by scanning electron and light microscopy, respectively. All epidermal development proceeded simultaneously during the 1st trimester with the exception of the foot which was more advanced in thickness and state of differentiation. During the 2nd trimester the epidermis of the head and the foot showed more precocious development, particularly in relation to the special sense organs and to the plantar surface. The interfollicular epidermis of the majority of the body was approximately equivalent in the state of development. These data have potential relevance to prenatal diagnosis of inherited skin disease from amniocentesis and/or fetal biopsy specimens; survey of the total epidermal surface allows prediction of the types of skin-derived cells that should be present in the amniotic fluid at a given age, allows evaluation of a fetal biopsy from 1 region and allows confidence that it is an accurate index of fetal skin development, age and status in general.