Amphetamine treatment during early postnatal development transiently restricts somatic growth.
Amphetamine treatment during early postnatal development transiently restricts somatic growth.
复制标题
产后早期发育期间的安非他明治疗会暂时限制体细胞生长。
DOI：
10.1016/j.lfs.2010.02.007
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发表时间：
2010
期刊：
影响因子：
6.1
通讯作者：
Chen,Wei-JungA
中科院分区：
文献类型：
--
作者：
Smith,AndrewM;Chen,Wei-JungA
目的胎儿期或出生后早期躯体生长受限被认为是成年期神经解剖学变化和行为障碍的预测指标。在这里，d-硫酸苯丙胺（AMPH）暴露在脑生长突增期对这个潜在的indicatorevaluated.MAIN METHODSRats收到0，5，15或25 mg/kg/天的AMPH通过两个每日胃内插管PD 4 -9的影响。从PD 1至21每隔一天收集一次体重数据，然后每周收集一次，直至PD 59。在PD 9，在最后一次安非他明处理后90分钟处死一个动物子集，并收集皮质、小脑和脑干的重量。还在PD 68上评估了来自年轻成年大鼠的这些脑区域的重量。关键发现在出生后早期发育期间暴露于SAMPH以剂量相关的方式限制了躯体生长，分配到AMPH 25和AMPH 15组的动物体重显著降低。然而，这在本质上是短暂的，在PD 21断奶后未观察到幼仔体重的显著差异。此外，没有差异，在任何年龄观察到作为结果的AMPH exposation. SIGNIFICANCE这些研究结果支持的想法，即发展AMPH暴露短暂限制躯体生长。此外，缺乏对脑重量的影响表明，AMPH差异影响躯体和大脑的生长。目前的研究结果表明，除了对体重的直接影响外，安非他明可能会改变生长速度，并增加与体重有关的成人疾病的风险。
AIMSRestricted somatic growth during fetal or early postnatal periods has been suggested to serve as a predictive indicator for neuroanatomical changes and behavioral impairments during adulthood. Here, the effects of d-amphetamine sulfate (AMPH) exposure during the brain growth spurt period on this potential indicator were evaluated.MAIN METHODSRats received 0, 5, 15 or 25mg/kg/day of AMPH via two daily intragastric intubations from PD4-9. Body weight data were collected every other day from PD1 to 21, and then weekly until PD59. On PD9, a subset of animals was terminated 90min after the last amphetamine treatment and the weights of the cortex, cerebellum, and brainstem were collected. Weights of these brain regions from young adult rats were also assessed on PD68.KEY FINDINGSAMPH exposure during early postnatal development limited somatic growth in a dose-related manner, with significantly lower body weights in animals assigned to the AMPH 25 and AMPH 15 groups. However, this was transient in nature, with no significant difference in weight observed after pups were weaned on PD21. Further, no differences in brain weight were observed at either age as a result of AMPH exposure.SIGNIFICANCEThese findings support the idea that developmental AMPH exposure transiently restricts somatic growth. Moreover, the lack of effect on brain weight shows that AMPH differentially affects somatic and brain growth. The current findings suggest that in addition to the immediate effects on body weight, amphetamine may alter the rate of growth, and increase the risk for weight-related adult diseases.