Oxidative Stress in Neurodegenerative Diseases.
Oxidative Stress in Neurodegenerative Diseases.
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DOI：
10.1007/s12035-015-9337-5
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发表时间：
2016-08
影响因子：
5.1
通讯作者：
Filip M
中科院分区：
文献类型：
--
作者：
Niedzielska E;Smaga I;Gawlik M;Moniczewski A;Stankowicz P;Pera J;Filip M
神经退行性疾病，包括肌萎缩侧索硬化症(ALS)、帕金森病(PD)和阿尔茨海默病(AD)，其病理生理机制还远未完全阐明。氧化应激(OS)被认为在神经退行性疾病的发病机制中起着潜在的作用。临床和临床前研究表明，神经退行性疾病的特点是脑组织和周围组织中OS生物标志物水平较高，而抗氧化防御生物标志物水平较低。在这篇文章中，我们在临床试验和动物研究的基础上，综述了关于OS参与神经退行性疾病的现有知识。此外，我们还分析了药物对氧化平衡的调节作用，并探索了降低OS的药物治疗策略。
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.
影响因子：
4.4
作者：
Nasr, Payman;Carbery, Timothy;Geddes, James W.
通讯作者：
Geddes, James W.