Effects of psychiatric medications on sleep and sleep disorders
Effects of psychiatric medications on sleep and sleep disorders
复制标题
DOI：
10.2174/187152707779940835
复制
发表时间：
2007-02-01
影响因子：
3
通讯作者：
Winokur, Andrew
中科院分区：
文献类型：
--
作者：
DeMartinis, Nicholas A.;Winokur, Andrew
疟疾是一个重大的公共卫生问题，促使人们做出巨大努力，制定治疗和管理战略。很大一部分失眠的投诉与精神疾病有关，如焦虑症和抑郁症，已知这些疾病的治疗对睡眠有直接和间接的好处，也对睡眠和睡眠生理产生一些负面影响。抑郁症也是许多其他精神疾病的突出症状，包括精神分裂症和双相情感障碍。观察到的各种精神病药物对失眠的影响，促使临床医生寻求替代已建立的药物治疗原发性失眠的精神病药物治疗非精神疾病相关的失眠的经验性实践。本文旨在回顾精神科药物对睡眠生理学、精神病患者睡眠障碍和原发性睡眠障碍影响的证据。潜在的开发相关的药理作用机制，在药物开发原发性失眠症也将得到解决。
Insomnia is a significant public health concern that has prompted substantial efforts to develop treatment and management strategies. A significant proportion of complaints of insomnia are related to psychiatric conditions such as anxiety disorders and depression, and treatments for these disorders are known to exert both direct and indirect benefits on sleep as well as some negative effects on sleep and sleep physiology. Insomnia is also a prominent symptom of a number of other psychiatric disorders, including schizophrenia and bipolar disorder. The observed impact of a variety of psychiatric medications on insomnia has prompted an empirically derived practice of treating non-psychiatric disorder-related insomnia with psychiatric medications by clinicians searching for alternatives to established medication treatments for primary insomnia. This article aims to review the evidence of the impact of psychiatric medications on sleep physiology, sleep disorders in psychiatric conditions, and on primary sleep disorders. The potential for exploiting the relevant pharmacological mechanisms of action in drug development for primary insomnia will be addressed as well.