Generation of cytotoxic singlet oxygen via phthalocyanine-stabilized gold nanoparticles: A potential delivery vehicle for photodynamic therapy
Generation of cytotoxic singlet oxygen via phthalocyanine-stabilized gold nanoparticles: A potential delivery vehicle for photodynamic therapy
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DOI：
10.1021/la0256230
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发表时间：
2002-04-16
期刊：
影响因子：
3.9
通讯作者：
Russell, DA
中科院分区：
文献类型：
--
作者：
Hone, DC;Walker, PI;Russell, DA
金纳米粒子已用酞菁 (Pc) 光敏剂稳定。透射电子显微镜证实包覆颗粒的尺寸为2-4 nm。能量色散 X 射线分析表明，Pc 大环存在于金表面，并且合成过程中使用的 TOAB 相转移试剂与纳米颗粒结合。与游离 PC 相比，三组分（光敏剂/金/相转移试剂）纳米颗粒可产生具有更高量子产率的单线态氧。此外，转移试剂的缔合促进了表面结合的疏水性敏化剂在极性溶剂中的溶解度，这将有利于它们的全身注射。结果表明，这些三组分结构有潜力作为光动力疗法中光敏剂递送的有用载体。
Gold nanoparticles have been stabilized with a phthalocyanine (Pc) photosensitizer. Transmission electron microscopy confirmed that the coated particles were in the 2-4 nm size regime. Energy-dispersive X-ray analysis revealed that the Pc macrocycle was present on the gold surface and also that the TOAB phase transfer reagent, used during the synthesis, was associated with the nanoparticles. The three-component (photosensitizer/gold/phase transfer reagent) nanoparticles were shown to generate singlet oxygen with enhanced quantum yields as compared to the free Pc. Additionally, the association of the transfer reagent promoted the solubility of the surface-bound hydrophobic sensitizer in polar solvents which would facilitate their systemic injection. The results suggest that these three-component structures have potential as a useful vehicle for the delivery of photosensitizer agents in photodynamic therapy.