Increased compactibility of acetames after roll compaction
Increased compactibility of acetames after roll compaction
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DOI：
10.1016/j.ejpb.2010.09.013
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Kleinebudde, Peter
中科院分区：
文献类型：
--
作者：
Kuntz, Theresia;Schubert, Martin A.;Kleinebudde, Peter
以连续方式制造颗粒的常用技术是辊压和随后的研磨的组合。辊压可显著影响材料的压片性能。本研究的目的是研究碾压/干法制粒对乙酰胺类活性药物（主要用于治疗中枢神经系统疾病）压制行为的影响。将一些代表性的乙醯胺进行辊压，然后压制成片剂。将颗粒的可压实性与直接压制的药物粉末的压实行为进行比较。与许多其他材料相比，辊压步骤引起所有研究的乙醯胺的可压实性增加。通过氮吸附测定未处理的和碾压的药物的比表面积。观察到的压实性的提高伴随着在碾压过程中比表面积的增加。(C)2010 Elsevier B. V.保留所有权利。
A common technique for manufacturing granules in a continuous way is the combination of roll compaction and subsequent milling. Roll compaction can considerably impact tableting performance of a material. The purpose of this study was to investigate the influence of roll compaction/dry granulation on the compaction behavior of acetames, a class of active pharmaceutical substances, which are mainly used for the treatment of central nervous diseases. Some representatives of acetames were roll compacted and then compressed into tablets. Compactibility of granules was compared with the compaction behavior of the directly compressed drug powders. In contrast to many other materials, the roll compaction step induced an increase in compactibility for all investigated acetames. Specific surface areas of the untreated and the roll compacted drugs were determined by nitrogen adsorption. The raise in compactibility observed was accompanied by an increase in specific surface area during roll compaction. (C) 2010 Elsevier B.V. All rights reserved.