Long-term intrathecal administration of midazolam and clonidine
Long-term intrathecal administration of midazolam and clonidine
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DOI：
10.1097/00002508-199603000-00012
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发表时间：
1996-03-01
影响因子：
2.9
通讯作者：
Krijnen, HJ
中科院分区：
文献类型：
--
作者：
Borg, PAJ;Krijnen, HJ
目的：确定长期鞘内注射咪达唑仑和可乐定对难治性神经源性和肌肉骨骼疼痛患者的临床有效性。地点：荷兰格罗宁根学术医院疼痛中心。患者：四名慢性良性神经源性和肌肉骨骼疼痛患者，对常规镇痛治疗无反应。结果指标：视觉模拟评分、日常生活活动。结果：鞘内注射咪达唑仑和可乐定几乎立即且几乎完全缓解疼痛。即使连续使用，耐受性似乎也没有问题，而且副作用似乎很小。结论：鞘内输注咪达唑仑和可乐定对四名难治性慢性良性疼痛患者产生了可喜的效果。需要进一步的研究来确定长期服用该组合的功效和风险效益比。
Objective: To determine the clinical usefulness of the long-term intrathecal administration of midazolam and clonidine in patients with refractory neurogenic and musculoskeletal pain.Setting: Pain Centre, Academic Hospital Groningen, Groningen, The Netherlands.Patients: Four patients with chronic benign neurogenic and musculoskeletal pain, not responding to conventional analgesic therapy.Outcome measures: Visual Analogue Score, Activities of Daily Living.Results: The intrathecal administration of midazolam and clonidine produced almost immediate and nearly complete pain relief. Even with continuous use, tolerance seemed to be no problem, and side effects appear to be minimal.Conclusion: Intrathecal infusion of midazolam and clonidine produced promising results in four patients with refractory chronic benign pain. Further research will be necessary to determine the efficacy and the risk-to-benefit ratio of long-term administration of this combination.