Antiviral treatment of chronic hepatitis B virus (HBV) infections.

Antiviral treatment of chronic hepatitis B virus (HBV) infections.
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DOI:
10.3390/v2061279
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发表时间:
2010-06
期刊:
Viruses
影响因子:
--
通讯作者:
Neyts J
Neyts J
中科院分区:
其他
文献类型:
--
作者:
De Clercq E;Férir G;Kaptein S;Neyts J

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虽然25种化合物已被正式许可用于治疗HIV感染(AIDS),但目前只有7种许可产品可用于治疗慢性B型肝炎病毒(HBV)感染:干扰素-α、聚乙二醇化干扰素-α、拉米夫定、阿德福韦酯(地昔单抗)、恩替卡韦、替比夫定和替诺福韦酯(富马酸二异山梨酯)。与常规联合使用单个药物的HIV感染治疗相反,对于慢性HBV感染的治疗,单个药物通常用于单药治疗。原则上,联合药物治疗应允许降低耐药性发展的可能性。
While 25 compounds have been formally licensed for the treatment of HIV infection (AIDS), only seven licensed products are currently available for the treatment of chronic hepatitis B virus (HBV) infection: interferon-α, pegylated interferon-α, lamivudine, adefovir (dipivoxil), entecavir, telbivudine and tenofovir (disoproxil fumarate). In contrast to the treatment of HIV infections where the individual drugs are routinely used in combination, for the treatment of chronic HBV infection the individual drugs are generally used in monotherapy. In principle, combination drug therapy should allow reducing the likelihood of drug-resistant development.
DOI: 10.1038/nrmicro975
发表时间: 2004-09
期刊: Nature reviews. Microbiology
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