Trends of rotavirus in Nepal.
Trends of rotavirus in Nepal.
复制标题
尼泊尔轮状病毒的趋势。
DOI：
10.3126/kumj.v9i1.6259
复制
发表时间：
2012
影响因子：
--
通讯作者：
S. Pun
中科院分区：
文献类型：
--
作者：
B. Pandey;S. Pun
背景
轮状病毒胃肠炎是全世界婴幼儿发病和死亡的主要原因。需要安全有效的轮状病毒疫苗才能对严重轮状病毒胃肠炎产生重大影响。目前，两种口服轮状病毒活疫苗已在许多国家获得许可。在将轮状病毒疫苗引入目标人群之前，了解 G 型和 P 型人类轮状病毒的分布至关重要。
目标
观察2003-2005年尼泊尔五岁以下儿童轮状病毒株的变化趋势。
方法
对 2003 年至 2005 年间转诊至观察室或在坎蒂儿童医院住院的急性腹泻儿童采集的粪便样本进行了检查。从尼泊尔环境部获得气象数据，以研究天气对轮状病毒感染影响的可能性。
结果
在 1250 份粪便标本中，Rotaclone ELISA 检测结果显示 271 份（22%）轮状病毒呈阳性。 G1 是第一年研究中最常见的血清型，G2 是第二年最常见的血清型。 G12血清型出现并连续两年保持主导地位。此外，G9和G3是在研究的第二年出现的。三岁以下的儿童通常受到影响。记录显示，轮状病毒感染与气候有关，多见于旱季，一月份达到高峰。
结论
需要对不同地区进行持续监测，以监测轮状病毒毒株的趋势并确定轮状病毒疾病负担，这将有助于政策制定者做出在尼泊尔引入轮状病毒疫苗的决定。
BACKGROUND
Rotavirus gastroenteritis is the major cause of morbidity and mortality in infants and young children worldwide. Safe and effective rotavirus vaccine is needed to have significant impact on severe rotavirus gastroenteritis. Currently, two live oral rotavirus vaccines have been licensed in many countries. Knowledge on distribution of human rotavirus of G and P types are essential before rotavirus vaccines are introduced in the target populations.
OBJECTIVE
To observe the trends of rotavirus strains in children below five years of age, during the years, 2003-2005 in Nepal.
METHODS
Stool specimen collected from children with acute diarrhea who were referred to observation unit or hospitalized in Kanti Children Hospital between 2003 and 2005 were examined. Meteorological data was obtained from Ministry of Environment, Nepal to examine the possibility on the impact of weather on rotavirus infection.
RESULTS
Of 1250 stool specimens, 271(22%) were positive for rotavirus by Rotaclone ELISA. G1 was the most common serotype in the first year of study, and G2 in the following year. G12 serotype emerged and remained predominant in two consecutive years. In addition, G9 and G3 emerged in the second year of the study. Children less than three years of age were commonly affected. The records reveal that rotavirus infection is related to the climate, and is commonly seen in the dry season, peaking in January.
CONCLUSIONS
Continued surveillance of different regions is needed to monitor the trend of rotavirus strains and to establish rotavirus disease burden, which will help policy makers to make a decision in introducing rotavirus vaccine in Nepal.