Serum adiponectin concentrations are decreased in women with endometriosis
Serum adiponectin concentrations are decreased in women with endometriosis
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DOI：
10.1093/humrep/dei233
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发表时间：
2005-12-01
影响因子：
6.1
通讯作者：
Taketani, Y
中科院分区：
文献类型：
--
作者：
Takemura, Y;Osuga, Y;Taketani, Y
背景：脂联素是一种多效性细胞因子，最初被发现是一种脂肪细胞特异性基因产物。据报道，在患有子宫内膜癌、乳腺癌和子宫肌瘤的女性中，血清脂联素浓度很低，这表明脂联素可能参与了这些雌激素相关疾病。因此，在本研究中，我们讨论了脂联素与子宫内膜异位症的相关性，这是一种雌激素依赖型疾病。方法：48例子宫内膜异位症患者和30例非子宫内膜异位症患者接受了腹腔镜手术。采集血样，用特定的酶联免疫吸附试验测定血清脂联素浓度。分析腹腔镜术所见与血清脂联素浓度的关系。结果：子宫内膜异位症患者血清脂联素浓度(中位数13.1mU g/ml；四分位数范围10.2~16.7)显著低于非子宫内膜异位症患者(15.9mU g/ml，13.5~19.5；P=0.008)。血清脂联素水平与美国生殖医学学会修订的子宫内膜异位症评分(R=-0.307，P=0.006)和粘连评分(R=-0.254，P=0.026)呈显著负相关。结论：脂联素参与了子宫内膜异位症的病理生理过程。
BACKGROUND: Adiponectin is a pleiotropic cytokine originally discovered as an adipocyte-specific gene product. Serum adiponectin concentrations have been reported to be low in women with endometrial cancer, breast cancer and uterine leiomyoma, suggesting possible involvement of adiponectin in these estrogen-related diseases. We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study. METHODS: Women with (n = 48) and without (n = 30) endometriosis undergoing laparoscopy were recruited in this study. Blood samples were collected, and serum adiponectin concentrations were measured using a specific enzyme-linked immunosorbent assay. The relationship between laparoscopic findings and serum adiponectin concentrations was analysed. RESULTS: The adiponectin concentrations in the serum of the women with endometriosis (median, 13.1 mu g/ml; interquartile range, 10.2-16.7) were significantly lower than those of the women without endometriosis (15.9 mu g/ml, 13.5-19.5; P = 0.008). A significant negative correlation was found between serum adiponectin concentrations and both endometriosis scores (R = -0.307, P = 0.006) and adhesion scores (R = -0.254, P = 0.026) of the revised American Society for Reproductive Medicine classification of endometriosis. CONCLUSIONS: The present findings suggest that adiponectin is implicated in the pathophysiology of endometriosis.