Near Full-Length Genome Sequence of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Detected Among Blood Donors in North China
Near Full-Length Genome Sequence of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/CRF07_BC) Detected Among Blood Donors in North China
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在华北地区献血者中检测到新型HIV-1第二代重组体（CRF01_AE/CRF07_BC）的近全长基因组序列
DOI：
10.1089/aid.2017.0111
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Shang H.
中科院分区：
文献类型：
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作者：
He W.;Han X.;An M.;Hai Y.;Chang L.;Liu C.;Wang L.;Shang H.
本研究从中国北方一名无偿献血者中分离到一种新的CRF01_AE/07_BC HIV-1重组体，在pol、vpr、env和nef基因区有5个断裂点。本研究表明，该重组体可能是来自男男性行为（MSM）人群中两个主要毒株的第二代重组体，CRF 07_BC片段属于中国MSM特有的CRF 07_BC谱系，CRF 01_AE片段属于中国北方MSM常见的CRF 01_AE谱系5。本研究结果支持MSM人群的高危献血行为，提示中国MSM人群HIV-1流行的复杂性，并呼吁更多人关注HIV-1新重组体筛查的有效性。
In this study, a novel CRF01_AE/07_BC HIV-1 recombinant form, with five breakpoints in thepol, vpr, env,andnefgene regions, was identified from a voluntary blood donor in North China. Our study showed that this HIV-1 recombinant form might be a second-generation recombinant form from two predominant strains in the men who have sex with men (MSM) population, with the CRF07_BC fragments belonging to a CRF07_BC lineage specific to Chinese MSM and the CRF01_AE fragments belonging to the CRF01_AE lineage 5 common among MSM in northern China. Our findings supported the high-risk blood donation behaviors of MSM, implied the increasing complexity of the HIV-1 epidemic among the Chinese MSM population, and called more attention to the effectiveness of the screening test for the growing number of new HIV-1 recombinant forms.