Active Path Selection of Fluid Microcapsules in Artificial Blood Vessel by Acoustic Radiation Force
Active Path Selection of Fluid Microcapsules in Artificial Blood Vessel by Acoustic Radiation Force
复制标题
声辐射力对人工血管内流体微胶囊的主动路径选择
DOI：
10.1143/jjap.48.07gk03
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发表时间：
2009
影响因子：
1.5
通讯作者：
K. Ishihara
中科院分区：
文献类型：
--
作者：
K. Masuda;Yusuke Muramatsu;S. Ueda;Ryusuke Nakamoto;Y. Nakayashiki;K. Ishihara
微米大小的微胶囊暴露在超声波下会坍塌。将这一现象用于药物传递系统(DDS)，不仅用于局部药物传递，还用于基因治疗，应该是可能的。然而，由于胶囊在血液流动中的运动无法控制，注射后混悬液中的胶囊在人体内扩散，提高给药效率是有限的。为了控制微胶囊的行为，引入了声辐射力。我们通过在人造血管中产生声辐射力来检测微囊密度的局部变化。此外，我们从理论上估计了胶囊在人工血管分叉点的主动路径选择所需的条件。我们观察到在不同的声辐射力作用下，在分叉点和分叉点下游的不同路径上胶囊密度的差异。将实验结果与理论结果进行了比较，根据胶囊的声辐射力和流体阻力计算了主动路径选择的条件。证明了控制胶囊流向血管中某一特定点的可能性。
Micrometer-sized microcapsules collapse upon exposure to ultrasound. Use of this phenomenon for a drug delivery system (DDS), not only for local delivery of medication but also for gene therapy, should be possible. However, enhancing the efficiency of medication is limited because capsules in suspension diffuse in the human body after injection, since the motion of capsules in blood flow cannot be controlled. To control the behavior of microcapsules, acoustic radiation force was introduced. We detected local changes in microcapsule density by producing acoustic radiation force in an artificial blood vessel. Furthermore, we theoretically estimated the conditions required for active path selection of capsules at a bifurcation point in the artificial blood vessel. We observed the difference in capsule density at both in the bifurcation point and in alternative paths downstream of the bifurcation point for different acoustic radiation forces. Comparing the experimental results with those obtained theoretically, the conditions for active path selection were calculated from the acoustic radiation force and fluid resistance of the capsules. The possibility of controlling capsule flow towards a specific point in a blood vessel was demonstrated.
使用超声波造影剂将酵母细胞捕获在超声波场内
DOI：
--
发表时间：
--
期刊：
Jpn.J.Appl.Phys. (Accepted)
影响因子：
--
作者：
Y.Yamakoshi;M.Koganezawa;Y.Yamakoshi
通讯作者：
Y.Yamakoshi